めん羊の血漿中カルシウム,無機リンおよびマグネシウム濃度に対するノルアドレナリン静脈内注入の影響〔英文〕

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Three ewes and three wethers fed high (0.59%) or low (0.18%) calcium diets containing 0.30% magnesium and 0.48% phosphorus were used to determine the effects of intravenous infusion of noradrenaline on plasma levels of Ca, inorganic P and Mg. The contribution of urinary mineral excretions to changes in plasma mineral concentrations induced by noradrenaline infusion were also studied. Sheep were intravenously infused with noradrenaline in saline at 1.5μg/kg•BW/min for 2 hours. Blood samples were taken from jugular catheters prior to the infusion and 1, 2, 3, 4 and 6 hours after the onset of infusion. Urine samples of ewes fed the low calcium diet were obtained at one hour intervals for 4 hours following the onset of noradrenaline infusion.Plasma Ca and Mg levels were decreased by the intravenous infusion of noradrenaline. Lowest mean values of plasma Ca and Mg across dietary calcium treatments were 85 and 80% of initial values 2 hours after the onset of infusion, respectively, and were significantly different from the saline infusion (P<0.05). Plasma inorganic P was also decreased by the noradrenaline infusion and the lowest value was observed 4 hours after the onset of noradrenaline infusion. There was no significant difference for these values between sheep on low or high calcium diets. Plasma FFA levels were rapidly increased by the noradrenaline infusion, and showed about six times initial values an hour after the onset of infusion. Three-fold increases in plasma glucose levels were observed 2 hours after the onset of noradrenaline infusion. Urinary Ca excretions increased significantly (P<0.05) an hour after the onset of noradrenaline infusion compared with those of the saline infusion, but the increase was about one mg/hour. Inorganic P and Mg excretions were not changed by the noradrenaline infusion. These results indicate that the infusion of noradrenaline caused decreases in plasma levels of Ca, inorganic P and Mg which were accompanied by increases in FFA and glucose levels. Changes in urinary excretions of these minerals could not account for the observed lower plasma levels of Ca, inorganic P and Mg induced by the infusion of noradrenaline. Dietary calcium levels did not affect the decreases in plasma mineral concentrations induced by noradrenaline.
社団法人日本畜産学会の論文

めん羊の血漿中カルシウム,無機リンおよびマグネシウム濃度に対するノルアドレナリン静脈内注入の影響〔英文〕

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