Effects of Antimicrobial Peptides Derived from the Beetle Allomyrina dichotoma Defensin on Mouse Peritoneal Macrophages Stimulated with Lipopolysaccharide
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概要
- 論文の詳細を見る
We previously reported that synthetic peptides, RLYLRIGRR-NH2 (peptide A) and RLRLRIGRR-NH2 (peptide B), derived from the beetle Allomyrina dichotoma defensin, showed antimicrobial activity against both Gram-positive and negative bacteria and suppressed lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) mRNA expression in a murine macrophage cell line. In this study, inhibitory effects of these peptides in LPS-induced mouse peritoneal macrophage activation were investigated. The supplement of peptide A to macrophages cultured with LPS resulted in a significant decrease in nitric oxide and TNF-α production. Furthermore, NF-κB activation was also blocked by addition of peptide A. These results indicated that peptide A blocked macrophage activation induced by LPS.
著者
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Yamakawa Minoru
Innate Immunity Laboratory National Institute Of Agrobiological Sciences
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Hirota Yoshikazu
Department Of Immunology National Institute Of Animal Health Ministry Of Agriculture Forestry And Fi
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Asaoka Ai
Innate Immunity Laboratory National Institute Of Agrobiological Science
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Motobu Maki
Department Of Immunology National Institute Of Animal Health Ministry Of Agriculture Forestry And Fi
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AMER Said
Department of Production Diseases, National Institute of Animal Health
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Yamada Manabu
Deparment of Applied Chemistry, Faculty of Engineering, Shizuoka University
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YAMADA Manabu
Department of Production Diseases, National Institute of Animal Health
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SAIDO-SAKANAKA Hisako
Innate Immunity Laboratory, National Institute of Agrobiological Sciences
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NAKAMURA Kikuyasu
Department of Production Diseases, National Institute of Animal Health
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Hirota Yoshikazu
Department of Chemical Technology, Faculty of Engineering, Osaka University
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