Correlation of Differential Expression of Silkworm Antimicrobial Peptide Genes with Different Amounts of Rel Family Proteins and Their Gene Transcriptional Activity
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概要
- 論文の詳細を見る
In the silkworm, Bombyx mori, antimicrobial peptide (AMP) genes are upregulated in the larval fat body by injection of bacteria and peptidoglycans (PGNs). The DAP-type PGN from Escherichia coli and Bacillus subtilis exhibited stronger elicitor activity for expression of AMP genes in B. mori than Lys-type PGN from Staphylococcus aureus, suggesting that differences in bacterial influence on the induction levels of these genes depend on the differences in types of PGN. BmRelish1 mRNA was more abundant than BmRel mRNAs in the larval fat bodies. Moreover, the ability of the BmRelish1 active form to enhance the promoter activity of AMP genes was higher than that of BmRels. The difference was related to the binding affinity of Rel family proteins to κB sites. Our results suggest that different amounts and different transcriptional activities of Rel family proteins result in differential activation of AMP genes by PGN type and bacterium species.
- 社団法人 日本農芸化学会の論文
- 2009-03-23
著者
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YAMAKAWA Minoru
National Institute of Agrobiological Sciences
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Yamakawa Minoru
Univ. Tsukuba Ibaraki Jpn
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Yamakawa M
National Inst. Agrobiological Sci. Ibaraki Jpn
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Yamakawa Minoru
Laboratory Of Biological Defenoe Department Of Insect Physiology And Behavior National Institute Of
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Yamakawa Minoru
Innate Immunity Research Unit National Institute Of Agrobiological Sciences
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Yamakawa Minoru
Innate Immunity Laboratory National Institute Of Agrobiological Sciences
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SAGISAKA Aki
Innate Immunity Research Unit, National Institute of Agrobiological Science
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Sagisaka Aki
Innate Immunity Research Unit National Institute Of Agrobiological Science
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Tanaka Hiromasa
Faculty Of Agriculture Iwate University
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Nakajima Yoshiro
Innate Immunity Laboratory, National Institute of Agrobiological Sciences
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Yamakawa Minoru
Graduate School Of Life And Environmental Sciences Univ. Of Tsukuba
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Nakajima Yoshiro
Innate Immunity Laboratory National Institute Of Agrobiological Sciences
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TANAKA Hiromitsu
Innate Immunity Research Unit, National Institute of Agrobiological Sciences
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FUJITA Kosuke
Innate Immunity Research Unit, National Institute of Agrobiological Sciences
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IMANISHI Shigeo
Genebank, National Institute of Agrobiological Sciences
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Tanaka H
Innate Immunity Laboratory National Institute Of Agrobiological Science
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Fujita Kosuke
Innate Immunity Research Unit National Institute Of Agrobiological Sciences
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Imanishi Shigeo
Genebank National Institute Of Agrobiological Sciences
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Sagisaka Aki
Innate Immunity Research Unit National Institute Of Agrobiological Sciences
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Nakajima Yoshiro
Innate Immunity Research Unit National Institute Of Agrobiological Sciences
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Tanaka Hiromitsu
Innate Immunity Laboratory National Institute Of Agrobiological Sciences
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