Efficacy and Safety of Mizoribine by One Single Dose Administration for Patients with Rheumatoid Arthritis

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概要

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• Objective Mizoribine (MZR) is an immunosuppressant that inhibits nucleic acid metabolism and is a relatively safe disease-modifying anti-rheumatic drug (DMARD). We evaluated the efficacy and safety of one single dose per day for patients with rheumatoid arthritis (RA). Patients and Methods In this study 32 patients with RA received MZR therapy. We evaluated the average dose of MZR and prednisolone, response to treatment and peak plasma level of MZR. Results The average dose of MZR was 146.1±31.2 (range: 50-200) mg/day. The average dose of prednisolone was 4.63±3.59 (range: 0-14) mg/day. The average plasma level of MZR, measured after 3 hours, was 2.20±0.49 μg/mL in the responder group and 1.59±0.82 μg/mL in the non-responder group (p=0.020). The treatment with MZR for 24 weeks was completed by 71.9% of patients and the proportion of patients who achieved a good and moderate response rate according to the European League Against Rheumatism (EULAR) criteria was 56.3% at 24 weeks. The plasma level of MZR which was greater than or equal to 2.12 μg/ mL was significantly correlated with the clinical response (p<0.01). Only one of thirty-two cases discontinued the treatment, because of skin eruption. Conclusion This study included patients that could not be treated with other DMARDs and/or biologic agents because of age, interstitial pneumonia and other complications. We show that MZR may be a useful and relatively safe therapy for patients in this group.

• The Japanese Society of Internal Medicineの論文

著者

• Nakamura Hideki

  Department of Cardiovascular Medicine, Abashiri Kohsei General Hospital

• Ida Hiroaki

  Department Of Internal Medicine School Of Medicine Nagasaki University

• UEKI Yukitaka

  Sasebo Chuo Hospital

• Arima Kazuhiko

  Department Of Clinical Chemistry And Laboratory Medicine

• TAMAI Mami

  Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki Universi

• KAMACHI Makoto

  Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki Universi

• TSUKADA Toshiaki

  Isahaya General Hospital

• Kawakami Atsushi

  Department Of Biological Information Tokyo Institute Of Technology

• Ichinose Kunihiro

  Department Of Immunology And Rheumatology Graduate School Of Biomedical Sciences Nagasaki University

• Kawashiri Shin-ya

  Department Of Immunology And Rheumatology Graduate School Of Biomedical Sciences Nagasaki University

• Fujikawa Keita

  Department Of Immunology And Rheumatology Graduate School Of Biomedical Sciences Nagasaki University

• Ueki Yukitaka

  Sasebo Central Hospital

• Eguchi Katsumi

  Department Of Endocrinology And Metabolism Unit Of Translational Medicine Graduate School Of Biomedi

• Aramaki Toshiyuki

  Department Of Immunology And Rheumatology Graduate School Of Biomedical Sciences Nagasaki University

• Iwamoto Naoki

  Department Of Applied Biological Chemistry Graduate School Of Agriculture Kinki University

• Origuchi Tomoki

  Department Of Locomotive Rehabilitation Science Unit Of Rehabilitation Sciences Nagasaki University Graduate School Of Biomedical Sciences

• Iwamoto Naoki

  Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University

• Origuchi Tomoki

  Department of Rehabilitation, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University

• Eguchi Katsumi

  Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University

• Fujikawa Keita

  Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University

• Aramaki Toshiyuki

  Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University

• Tsukada Toshiaki

  Isahaya Health Insurance General Hospital

• Kamachi Makoto

  Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University

• Ida Hiroaki

  Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University

• Kawashiri Shin-ya

  Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University

• Ichinose Kunihiro

  Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University

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