Hepatocellular Carcinoma in a Hokkaido Brown Bear (Ursus arctos yesoensis)
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概要
- 論文の詳細を見る
Hepatocellular carcinoma with metastases to lymph nodes and adrenal glands was found in a 26-year-old male Hokkaido brown bear (Ursus arctos yesoensis). Left hepatic lobe was largely replaced by well-differentiated neoplastic cells, whereas poorly differentiated tumor cells had proliferated in part of the left hepatic lobe, in scattered nodules in the remainig liver tissue, and at the metastatic sites. Immunoreactivity for hepatocyte antigen (hepatocyte paraffin 1 antibody) and alpha-fetoprotein was observed in both well- and poorly differentiated neoplastic cells in the liver and metastatic foci. To our knowledge, this case is the first report of hepatocellular carcinoma in brown bears.
著者
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KAWAMURA Yoshio
Department of Materials Science and Engineering, Graduate School of Engineering, Osaka University
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Suzuki Hiromi
Department of Toxicology and Pathology, Nippon Roche Research Center
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MATSUDA Kazuya
Department of Applied Chemistry, School of Science and Engineering, Waseda University
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SAKAMOTO Hideyuki
Noboribetsu Bear Park
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Taniyama Hiroyuki
Department Of Veterinary Pathology School Of Veterinary Medicine Rakuno Gakuen University
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Qiu Yongjin
Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University
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TAKITA Yuko
Noboribetsu Bear Park
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SASAKI Kazuyoshi
Noboribetsu Bear Park
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Matsuda Kazuya
Department Of Veterinary Pathology School Of Veterinary Medicine Rakuno Gakuen University
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Matsuda Kazuya
Department Of Applied Chemistry School Of Science And Engineering Waseda University
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Suzuki Hiromi
Department Of Brain Function Research Institute Of Environmental Medicine Nagoya University
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Kawamura Yoshio
Department Of Material Science And Engineering Osaka University
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TANIYAMA Hiroyuki
Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University
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TANIYAMA Hiroyuki
Department of Veterinary Pathobiology, Rakuno Gakuen University
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