Epidermal Growth Factor Receptor Expression in Canine Transitional Cell Carcinoma
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概要
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Transitional cell carcinoma (TCC), a urinary bladder tumor with high mortality, is encountered commonly in dogs. Whereas overexpression of epidermal growth factor receptor (EGFR) is associated with development of human urinary bladder cancer, information on EGFR expression in canine TCC is lacking. In this study, EGFR protein and mRNA expression in canine normal bladder (n=5), polypoid cystitis (n=5) and TCC (n=25) were examined by immunohistochemistry and real-time polymerase chain reaction. EGFR protein expression was significantly higher in TCC than that in normal healthy bladder (P<0.001) and polypoid cystitis (P<0.005). High EGFR protein expression was significantly (P<0.01) associated with TCC with a sensitivity of 72% and specificity of 100%. Comparative analysis of protein and mRNA expression levels in TCC showed significant positive correlation (r=0.88, P<0.05) between mRNA and protein expression. These findings suggest that intense expression of EGFR protein could be used as a marker to help canine TCC diagnosis.
- 公益社団法人 日本獣医学会の論文
著者
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Fukumoto Shinya
Department Of Metabolism Endocrinology And Molecular Medicine Osaka City University Graduate School
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Kawamura Yoshio
Department Of Material Science And Engineering Osaka University
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UCHIDE Tsuyoshi
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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HANAZONO Kiwamu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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KADOSAWA Tsuyoshi
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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IWANO Hidetomo
Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan
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KADOSAWA Tsuyoshi
Department of Companion Animal Clinical Science, School of Veterinary Medicine, Rakuno Gakuen University
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ENDO Yoshifumi
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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