換気—血流mismatch症例を対象とした胸部X線動態撮影法によるV/Q studyの検証

概要

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Pulmonary ventilation and blood flow are reflected in dynamic chest radiographs as changes in X-ray translucency, i.e., pixel values. Thus, relative local pulmonary function can be evaluated based on changes in pixel value. The purpose of this study was to investigate the feasibility of ventilation-perfusion evaluation (V/Q study) based on changes in pixel value in dynamic chest radiographs. Sequential chest radiographs of a patient with ventilation-perfusion mismatch were obtained with a dynamic FPD system. The changes in pixel value resulting from respiration and blood flow were measured in respiratory phase and breath-holding phase, respectively, and the radio was calculated in each local area. The results were compared to distribution of radioactivity counts and V/Q. In the results, abnormalities were appeared as a reduction of changes in pixel values, and a correlation was observed between the distribution of changes in pixel value and those of radioactivity counts (Ventilation; r=0.78, Perfusion; r=0.77) . Ventilation-perfusion mismatch was also indicated as mismatch of changes in pixel value, and a correlation with V/Q calculated by radioactivity counts (r=0.78) . The present method is potentially useful for V/Q study as an additional examination in conventional chest radiography.
医用画象情報学会の論文