The significance of podoplanin expression in human inflamed gingiva
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概要
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Podoplanin, a transmembrane glycoprotein, has been considered to be expressed specifically by lymphatic endothelial cells. However, recent studies have shown that the protein is expressed in a variety of normal as well as neoplastic tissues, and that its expression might be related to cell migration and invasion. In this study, we examined podoplanin expression in inflamed gingival tissues using an immunohistochemical method. Positive immunoreactivity for podoplanin was found in the cell membrane and cytoplasm of basal cells of oral gingival epithelium when severe inflammatory cell infiltration was present in the connective tissue just under the epithelium. When inflammatory changes were weak or absent, little or no reactivity for podoplanin in the basal cells was observed. Positive reactivity for podoplanin was also detected in basal cell extensions. Surprisingly, strong immunoreactivity for podoplanin was observed in all layers of oral sulcular and junctional epithelia associated with severe inflammatory reaction in the connective tissue. These findings suggest that increased expression of podoplanin in gingival epithelium is related to the progression of chronic periodontitis. (J Oral Sci 51, 283-287, 2009)
著者
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Kusama Kaoru
Division Of Pathology Department Of Diagnostic And Therapeutic Sciences Meikai University School Of
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Nemoto Norimichi
Department Of Iind Pathology Nihon University School Of Medicine
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González-Alva Patricia
Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School o
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KIKUCHI Kentaro
Division of Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine
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Sakashita Hideaki
Second Department Of Oral And Maxillofacial Surgery Meikai University School Of Dentistry
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OCHIAI Kuniyasu
Department of Bacteriology, Nihon University, School of Dentistry
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Okamoto Eri
Second Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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Miyazaki Yuji
Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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Hayashi Joichiro
Division of Periodontology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry
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Ishige Toshiyuki
Department of Pathology, Nihon University School of Medicine
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Shin Kitetsu
Division of Periodontology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry
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Kikuchi Kentaro
Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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Sakashita Hideaki
Second Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
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Kikuchi Kentaro
Division of Pathology, Department of Diagnostic & Therapeutic Sciences, Meikai University School of Dentistry
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Miyazaki Yuji
Division of Pathology, Department of Diagnostic & Therapeutic Sciences, Meikai University School of Dentistry
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