ATP-and Adenosine-Mediated Signaling in the Central Nervous System : Purinergic Receptor Complex : Generating Adenine Nucleotide-Sensitive Adenosine Receptors
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概要
- 論文の詳細を見る
Adenosine A1 receptors (A1R) are able to form a heteromeric complex with P2Y1 receptors (P2Y1R) that generates A1R with P2Y1R-like agonistic pharmacology. A potent P2Y1R agonist, adenosine 5-O-(2-thiotriphosphate), binds the A1R binding pocket of the A1R/P2Y1R complex and inhibits adenylyl cyclase activity via Gi/o protein. These mechanisms might be used to fine-tune purinergic inhibition locally at sites where there is a particular oligomerization structure between purinergic receptors and explain the undefined purinergic functions by adenosine and adenine nucleotides.
- 社団法人 日本薬理学会の論文
- 2004-02-01
著者
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Yoshioka Kazuaki
Department Of Physiology Kanazawa University
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Yoshioka Kazuaki
東京都医学研究機構東京都神経科学総合研究所
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Yoshioka Kazuaki
Department Of Molecular Cell Signaling Tokyo Metropolitan Institute For Neuroscience
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NAKATA Hiroyasu
Department of Physics, Graduate School of Science, Osaka University
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Nakata Hiroyasu
Department Molecular Cell Signaling Tokyo Metropolitan Institute For Neuroscience
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Yoshioka Kazuaki
Department Of Biotechnology Faculty Of Technology Tokyo University Of Agriculture And Technology
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