Relationship between Porphyromonas gingivalis, Epstein-Barr virus infection and reactivation in periodontitis
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概要
- 論文の詳細を見る
The aim of this study was to assess the relationship between Porphyromonas gingivalis, Epstein-Barr virus (EBV) infection and reactivation in periodontitis using real-time PCR. The mean proportion of P. gingivalis cells to total bacterial cells in the saliva from EBV-positive periodontitis patients was significantly higher than that in saliva from EBV-negative patients. An EBV-positive B-cell line was used to determine whether P. gingivalis sonicate induced reactivation of EBV, using real-time PCR to measure the virus genome in the culture medium. A significant increase in EBV numbers was observed after the stimulation with P. gingivalis sonicate. These findings suggest that the interaction between EBV and P. gingivalis is bi-directional, with EBV reactivation suppressing host defenses and permitting overgrowth of P. gingivalis, and P. gingivalis having the potential to induce EBV reactivation. (J. Oral Sci. 46, 203-206, 2004)
- 日本大学歯学部の論文
著者
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Sugano Naoyuki
Department Of Periodontology Nihon University School Of Dentistry
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Ito Koichi
Department Of Biomedical Sciences Hirosaki University Graduate School Of Health Sciences
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Sato Shuichi
Department Of Gastroenterology And Hepatology Shimane University School Of Medicine
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Tanaka Hajime
Department Of Applied Physics And Applied Mechanics Institute Of Industrial Science University Of To
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Ikeda Kyoko
Nihon University Graduate School of Dentistry
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Oshikawa Maiko
Department of Periodontology, Nihon University School of Dentistry
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Idesawa Masataka
Department of Periodontology, Nihon University School of Dentistry
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TANAKA HAJIME
Department of Applied Chemistry, Faculty of Engineering, Utsunomiya University
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