Relationships Between Serum Unsaturated Fatty Acids and Coronary Risk Factors Negative Relations Between Nervonic Acid and Obesity-Related Risk Factors:Negative Relations Between Nervonic Acid and Obesity-Related Risk Factors

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概要

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• Relative increases in unsaturated fatty acids (USFA) in the diet are considered to exert beneficial effects on coronary risk factors (CRF). However, detailed analysis of the relationships between serum USFA and CRF are scanty and there is no report of the relationship between nervonic acid (NA) and CRF. The objective of the present study was to analyze the relationships between serum USFA and CRF. Body height and weight, blood pressure, fasting serum total cholesterol (TC), triacyl-glycerol (TG), HDL cholesterol (HDLc), fasting blood sugar (FBS), total fatty acid composition, leptin, and high-sensitivity C-reactive protein (CRP) were measured in 31 men (age, 41-78 years) and 11 women (age, 54-77 years). The relationships between serum USFA, and body mass index (BMI), leptin, systolic blood pressure (SBP), diastolic blood pressure (DBP), TC, TG, HDLc, FBS, and CRP were analyzed using multiple regression analysis. The final results were summarized using coronary risk factor scores (CRFS) in order to assess the correlations between USFA with CRF. Oleic acid (OA), linoleic acid (LA), and eicosapentaenoic acid (EPA) were positively related to coronary risk factors (total CRFS = 2, 3, and 4, respectively), while nervonic acid (NA) exerted negative effects on these risk factors (total CRFS = −6 ). It is concluded NA may have preventive effects on obesity-related metabolic disorders.

• International Heart Journal刊行会の論文

著者

• Oda Eiji

  Department Of Internal Medicine Niigata Prefectural Yoshida Hospital

• Watanabe Kenichi

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmac

• Aizawa Yoshifusa

  Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M

• Hatada Katsuharu

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences

• Hatada Katsuharu

  Division of Cardiology, Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Science

• Thanikachalam Punniyakoti

  Department of Clinical Pharmacology, Niigata College of Pharmacy

• Kimura Jun

  Division of Cardiology, Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Science

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