Does Postoperative Serum Interleukin-6 Influence Early Recurrence after Curative Pulmonary Resection of Lung Cancer?
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概要
- 論文の詳細を見る
Purpose: We examined the influence of inflammatory cytokine levels on postoperative early recurrence in patients who underwent curative lung cancer surgery. Methods: In 107 patients who underwent curative pulmonary resections for non-small cell lung cancer (NSCLC) from November 2007 to June 2008, we measured serum interleukin-6 (IL-6) levels preoperatively, and on postoperative day (POD) 0, 1, and 2. Between July 2009 and August 2009, 1 year after the date of enrollment of the last patient, we investigated survival status of each patient and identified a group with recurrence.Results: Among 107 patients, 29 patients developed recurrence with a mean follow-up of 18.1 months (range 14 to 21). P-stage was significantly more advanced in the recurrence group than in the non-recurrence group (p = 0.005). Serum IL-6 levels on POD 1 were significantly higher in the recurrence group than in the non-recurrence group (p = 0.007). In Coxs proportional hazards regression, P-stage and serum IL-6 levels on POD 1 were significant independent predicting factors for postoperative early recurrence (p = 0.006, p = 0.003).Conclusions: The higher the serum IL-6 levels on POD 1, the higher the risk of early postoperative recurrence, even when curative pulmonary resection can be accomplished in lung cancer patients.
- 2011-10-01
著者
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Watanabe Kenichi
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmac
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Goya Tomoyuki
Department Of Surgery Ii Kyorin University Hospital
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Shiraishi Yuji
Section Of Chest Surgery Fukujuji Hospital
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Suda Kazuharu
The Second Department Of Surgery Kyorin University School Of Medicine
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Suda Kazuharu
Department Of Chest Surgery Saitama Cardiovascular And Respiratory Center
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Kita Hidefumi
The Second Department Of Surgery Kyorin University School Of Medicine
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Koshiishi Yoshihiko
Department Of Surgery Ii School Of Medicine Kyorin University Lung Cancer Task Force The Japanese Jo
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KITA Hidefumi
Section of Chest Surgery, Fukujuji Hospital
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OHTSUKA Kouki
Department of Laboratory Medicine, Kyorin University School of Medicine
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Ohtsuka Kouki
Department Of Laboratory Medicine Kyorin University School Of Medicine
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Kita Hidefumi
Section Of Chest Surgery Fukujuji Hospital
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Goya Tomoyuki
Department Of General Thoracic Surgery Kyorin University School Of Medicine
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