Establishment of Transplantable Rat Prostate Carcinomas from Primary Lesions Induced by 3,2'-Dimethyl-4-aminobiphenyl and Testosterone.
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概要
- 論文の詳細を見る
Six transplantable rat prostate carcinoma lines were established from primary tumors developing in the dorsolateral prostate and a metastatic lesion in the liver of F344 rats receiving a combined treatment with 3,2'-dimethyl-4-aminobiphenyl (DMAB) and testosterone propionate (TP). Growth in the subcutis of nude mice (ICR-nu/nu) is rapid with a doubling time of approximately 10 days and transplantability is 100%. The histological appearance of the transplanted tumors (well- to moderately differentiated and poorly differentiated adenocarcinomas) is very similar to that of the primaries and their structures have not been altered by after 8 passages. Lung metastasis has been observed at frequencies of 30 to 100%. Androgen receptor immunohistochemistry revealed all to be negative. These data indicate that the lines should prove useful for studies of invasion, metastasis, and hormone dependency of prostate carcinomas.
- 日本毒性病理学会の論文
著者
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Futakuchi Mitsuru
First Department Of Pathology Nagoya City University Medical School
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SHIRAI Tomoyuki
First Department of Pathology, Nagoya City University Medical School
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CUI Lin
First Department of Pathology, Nagoya City University Medical School
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MORI Toshio
First Department of Pathology, Nagoya City University Medical School
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Shirai Tomoyuki
First Department Of Pathology Nagoya City University Medical School
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Ito Nobuyuki
First Department Of Pathology Nagoya City University Medical School
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Takahashi Satoru
First Department Of Biochemistry School Of Pharmaceutical Sciences Kyushu University Of Health And W
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Sato Koji
First Department of Pathology, Nagoya City University Medical School
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Futakuchi Mitsuru
First Department of Pathology, Nagoya City University Medical School
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