Evaluation of Polyethylene Glycol as a Water-soluble Marker: Absorption and Excretion of 14C-labeled Polyethylene Glycol in Rats
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概要
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The absorbability of polyethylene glycol (PEG), a water-soluble nutritional marker, from the gastrointestinal tract of rat was examined using the [14C]-labeled compound ([14C]PEG) having a molecular weight of 4000. Intravenously injected [14C]PEG was readily excreted and recovered almost completely in the urine and neither hepatic nor renal uptake of the PEG was observed. Intragastrically administered [14C]PEG was eliminated in the urine with an average recovery of only 0.43±0.13% (Mean+S.D., n= 10) of the dose over 24hr. From the gel column chromatographic profile of the radioactivity excreted in the urine after an oral dose, [14C]PEG was suggested to be absorbed in two forms, as an original form and as a low molecular weight component. The latter component might be the degraded product of PEG in the gastrointestinal tract. From these results it was confirmed that PEG with a molecular weight of 4000 is a satisfactory marker because of its low absorbability.
- 社団法人 日本農芸化学会の論文
著者
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IMAIZUMI Katsumi
Department of Food Science and Technology, Faculty of Agriculture, Kyushu University
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Imaizumi Katsumi
Department Of Bioscience And Biotechnology Graduate School Of Kyushu University
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Takahashi Takao
Department Of Breast Oncology Saitama International Medical Center Saitama Medical University
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Sugano Michihiro
Deparment Of Food Science And Technology Faculty Of Agriculture Kyushu University
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FURUICHI Yukio
Department of Agricultural Chemistry, Faculty of Agriculture, Mie University
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