ペントバルビタール麻酔がラット海馬抗酸化能に及ぼす影響

概要

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It has been suggested that oxidative processes are involved in a variety of pathological conditions, notably ischemia-reperfusion injury. Moreover, anesthetics appear to exert differential effects on the severity of such injury, these being unlikely wholly attributable to their differential effects on oxidative stress. It is possible that these variable effects of anesthetics on this type of injury may be due, at least in part, to changes in the production of free radicals and/or in their detoxification by endogenous antioxidant enzymes. We have attempted to explore the latter possibility by measuring antioxidant ability under the freely moving state. For comparison, analyses were also performed to measure with X-band EPR spectroscopy the eliminating ratio (i.e. half-life) of carbamoyl-PROXYL exogenously applied into rats hippocampus by in vivo microdialysis. Results indicated that half-life in rats anesthetized with pentobarbital (PBT) was significantly shortened compared with control. Our findings, therefore, support the proposal that the influence of anesthesia by PBT involves effects at the increased antioxidant ability in the hippocampus.
日本医学館,Magnetic resonance in medicineの論文