超大孔径膜血液濾過および超大孔径膜二重血液濾過(<特集>敗血症とアフェレシス)

概要

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Super high-flux hemofiltration is a novel hemofiltration modality using super high-flux or high cut-off membrane that is characterized by an increased effective pore size designed to facilitate the elimination of inflammatory mediators. Several experimental and clinical studies showed favorable increase of sieving coefficient and therefore clearance of inflammatory cytokines with super high-flux hemofiltration. However, super high-flux hemofiltration could not achieve clinically sufficient clearances of mediators and outcomes because the amount of substitution fluid is limited. Recently we developed a new modality using a double filtration method called super high-flux double hemofiltration to overcome such limitations. Ex vivo data showed a greater clearances of mediators without an increase of substitution fluid. In addition, on-line super high-flux hemofiltration could be an alternative modality to overcome the limitation.
2012-05-31