MNM-P5-3 細胞ビーズを使用した三次元培養皮膚モデルの作製(P5 マイクロ・ナノ技術によるロボティクス・メカトロニクスの新展開)

概要

論文の詳細を見る
We proposed a method to fabricate 3D skin tissue models using cell beads. We prepared large numbers of monodisperse collagen gel beads by three-dimensional microfluidic device. Micro-tissue unit, "cell beads", are obtained by seeding 3T3 fibroblast cells over the collagen gel beads. We molded cell beads into the disk shaped PDMS well and incubated for 17 hours at 37℃. After the incubation, centimeter-scale and 800-μm thick fibroblast cell sheet was constructed, and we could easily release it from the well. We believe that this method should allow rapid fabrication of complex 3D skin tissue models that mimic microscopic tissue structures in vivo by combining different types of cell beads.
一般社団法人日本機械学会の論文
2010-10-12