良性乳児けいれん(福山)の臨床的・脳波学的・遺伝学的研究

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We evaluated 212 patients diagnosed as having benign infantile convulsions (BIC) who visited Tokyo Women's Medical College, Department of Pediatrics, between 1967 and 1992. They were grouped into three distinct clinical conditions, as follows; 116 classical BIC as described by Fukuyama (group F), 27 associated with diarrhea (group D) and 10 whose seizures were partial (group P). Another 58 appeared to belong to group F or P but their outcomes were not confirmed (group U). The age of onset was higher in group D than in group F or P. As for seizure type, the most common was generalized tonic-clonic seizure (53.8%), but the there were very few in whom seizures were observed from the beginning. Seizures occurred in clusters in 50.9%. The seizure frequency tended to be higher in younger children although the mean duration of illness was only 3 months regardless of age. Interictal EEGs presented age-dependent abnormalities such as rolandic discharge in 13.6%. All EEG normalized with aging, however. The rate of BIC among siblings of BIC probands was 6.6%, which is high in comparison to the prevalence rate of convulsions other than febrile convulsions in the general population of Japan. It was suggested that BIC are transient or functional disorders associated with brain development and that the cause is at least partially genetic. BIC can thus be distinguished from other epilepsies. Knowledge of this condition will greatly facilitate relieving patients of needless anxiety.
東京女子医科大学の論文
1997-03-25

良性乳児けいれん(福山)の臨床的・脳波学的・遺伝学的研究

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