恙蟲病々毒接種ノ抗體産生機能ニ及ボス影響 : 第6回報告 考察篇
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概要
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In the author's previously published Reports, I-V inclusive, he has reported that he experimented on the influence of inoculation with Tsutsugamushi virus upon the function of the production of various antibodies-agglutinin of the bac. typhosus group, vibrio cholerae, the bac. dysenteriae group, bac. proteus X 19, staphilococeus pyogenes, haemolysin and praecipitin; and that as the result of these studies he concluded that the special and considerable increase of antibody production by inoculation with Tsutsugamushi virus is a phenomenon which can be observed selectively only in the bac. typhosus group, especially in bac. typhosus. The purpose of the present experiment was to examine the cause of the phenomenon. The following are the conclusions: 1) It can be observed as a result of the writer's experiment with the Adler-Reimann methode, that the injection of Tsutsugamushi virus has no influence on the function of the R.E.S. of rabbits inoculated with the virus. 2) The above observation Shows that there is no close connection between the phenomenon and the function of the R.E.S. as he previously thought. 3) The temperature-rise and the alteration of the physico-chemical character of blood, and particularly, the increase of cholesterin in the blood of animals inoculated with the Tsutsugamushi virus, appear to have some connection with the cause of the phenomenon. 4) The phenomenon appears to be a non-special rise in the agglutinating power caused by the stimulus of the pathogen of Tsutsugamushi disease; but the mechanismus of the phenomenon is not always in accord with that of universal non-special rise in antibody production. 5) The mechanismus of the phenomenon is also different from that of Kuhn's so-called "paragglutination", and therefore should be distinguished from the cause of Weil-Felix's reaction in typhus exanthematicus. 6) Upon these observations above mentioned the author constructed the hypothesis that the phenomenon was caused by the existence of common antigen between the pathogen of Tsutsugamushi disease and bac. typhosus. Additional experiments conducted in the light of this theory have led to the conclusion that the phenomenon may properly be regarded as caused by receptor-commonness.
- 京都府立医科大学の論文
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