恙蟲病々毒接種ノ抗體産生機能ニ及ボス影響 : 第1回報告 ちふす菌凝集素ニ關スル研究
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It is already known that the Reticulo-Endothelial System has the function of producing antibodies and it has also been made clear that the pathogen of Tsutsugamushi disease has a special tendency to invade the reticulo-endothelial cells. From these facts, the author has conceived the opinion that there seems to be a certain relationship between the function of the production of antibodies and the injection of Tsutsugamushi virus. The purpose of the present experiments was to find out what this relation is. This first Report shows the results of the experimental studies on the influence of injection of Tsutsugamushi virus upon the production of bacillus typhosus agglutinin in rabbits. The following are thee conclusions: 1) The injection of Tsutsugamushi virus raises considerably the normal power of agglutinating bacillus typhosus. The injection of variola virus as a control also raises the power of agglutinating this bacillus, but the injection of Tsutsugamushi virus raises it to a much higher degree. 2) The power of agglutination is highest about the 12th day after the injection. This is completely in accord with the fact that Widal's reaction is often positive in the period of convalescence from Tsutsugamushi disease and therefore the author is of the opinion that the most careful attention is necessary in the practical application of Widal's test to the differential diagnosis of the Tsutsugamushi disease and Typhus abdominalis. 3) The injection of Tsutsugamushi virus also raises considerably the production of bac. typhosus immune agglutinin. The results of injecting variola virus are similar to the above, but there is a great difference in the degree and in the period when the power of agglutination is highest. 4) The fact that the injection of Tsutsugamushi virus raises considerably the production of immune agglutinin can be made use of to obtain immune sera with antibodies of the greatest possible power. 5) The author is of opinion that such specific raising of the production of agglutinin by the injection of Tsutsugamushi virus is probably due to the specific affinity between the pathogen of Tsutsugamushi disease and the R.E.S., which is regarded as the place where all antibodies are produced.
- 京都府立医科大学の論文
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