P-13 放線菌S. antibioticusの新奇シデロフォアの構造決定(ポスター発表の部)

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Iron acquisition is a vital process for bacteria to survive, since indispensable proteins such as chytochromes require iron to function properly. In aqueous solution, iron exists as two charged ionic form Fe(II) or three charged one Fe(III). These ferric ions are constantly insufficient in natural environments because the solubility of ferric ion is as low as 10-18M in water of biological pH, while optimum growth of one bacterial cell needs 1um of iron. In order to utilize such a low concentration of ferric ion in natural habitats, bacteria excrete low molecular compounds called siderophores, which have the ability to chelate ferric ion. Streptomycetes are gram-positive bacteria which are important as a source of bioactive compounds. In the soil where Streptomycetes dwell, it is competitive to acquire enough amount of iron to grow. Recently new kind of the peptide siderophore, coelichelin, was found in Streptomyces coelicolor by the combination of genome-mining and chemical analysis. This finding prompted us to explore the diversity of the siderophore among streptomycetes and accomplish the screening in search for new siderophore. On the course of the screening, we found new peptide siderophore named antichelin. By several separation steps, the compound was isolated with high purity. The structure of antichelin was determined by analyses of NMR and TOF-MS spectral data. As a result, antichelin was turned out to be the related compound to known siderophores such as foroxymithine and antichelin. Previously, we found that the inoculation of foroxymithine caused rapid aerial formation to S. coelicolor. There is the possibility that this kind of siderophore may function as a signal for deficiency of iron. We are interested in the biological role of this class of siderophores for the cell of streptomycetes besides iron uptake, and the further investigation to pursue this possibility will be continued.
天然有機化合物討論会の論文
2007-08-24

P-13 放線菌S. antibioticusの新奇シデロフォアの構造決定(ポスター発表の部)

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