74(PB2-4) マンネンタケ(Ganoderma lucidum)の産生するトリテルペノイド成分(ポスター発表の部)

概要

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The fungus Ganoderma lucidum (Polyporaceae) has been used as a home remedy in China and Japan. Recently, we have isolated four novel triterpenoids (1)〜(4) from the fruiting body and eleven novel triterpenoids (8)〜(18) from the cultured mycelial mat of a G. lucidum strain, which mainly produces bitter C_<27> lucidenic acids. Their structures were determined by spectroscopic methods. 1〜3 have an α,β-epoxyalcohol group in the side chain and its absolute configuration was elucidated by lanthanide induced Cotton effect in CD spectrum. On the other hand, 4 has the α,β-unsaturated aldehyde group, and 8〜18 have the α,β-unsaturated carboxyl group in the side chain. The biogenetic relationship between these components and the C_<27> lucidenic acids remains to be solved, particularly in respect to the oxidative cleavage of the side chain between C-24 and C-25.
1987-07-25