Anti-plasmodial and Cholinesterase Inhibiting Activities of some Constituents of Psorospermum glaberrimum

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概要

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• Glaberianthrone (1), a new bianthrone was isolated from the hexane extract of the stem bark of Psorospermum glaberrimum together with thirteen known compounds: 3-geranyloxyemodin anthrone (2), friedelan-3-one (3), 3-prenyloxyemodin anthrone (4), 3-geranyloxyemodin (5), 3-prenyloxyemodin (6), friedelan-3-ol (7), acetylvismione D (8), betulinic acid (9), 2-geranylemodin (10), bianthrone A2b (11), bianthrone 1a (12), emodin (13) and 2-prenylemodin (14). The structures of the isolated compounds were established by means of spectroscopic methods. The extracts and the isolated compounds were tested in vitro for their anti-plasmodial activity against Plasmodium falciparum (chloroquine resistant strain W2) and for their acetyl- and butyrylcholinesterase inhibitory properties. The n-hexane extract showed good anti-plasmodial activity against P. falciparum W2 strain, with IC_<50> of 0.87μg/ml. It also exhibited 65.5% and 98.2% of acetyl- and butyrylcholinesterase inhibition at 0.2mg/ml, respectively. Compounds 2 and 8 showed the best potencies against P. falciparum W2 strain with IC_<50> of 1.68μM and 0.12μM, (0.66μg/ml and 0.054μg/ml) respectively. All tested compounds showed good butyrylcholinesterase inhibition activities with compound 12 displaying the best potency (IC_<50> 9.25±0.25μM). All the tested compounds showed weak inhibitory activity against acetylcholinesterase.

• 社団法人日本薬学会の論文
• 2008-02-01

著者

• CHOUDHARY Muhammad

  H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Ka

• Choudhary M

  International Center For Chemical Sciences H.e.j. Research Institute Of Chemistry University Of Kara

• Choudhary Muhammad

  H.e.j. Res. Inst. Of Chemistry International Center For Chemical And Biological Sciences Univ. Of Ka

• Choudhary Muhammad

  H.e.j. Research Institute Of Chemistry International Center For Chemical And Biological Sciences Uni

• Choudhary Muhammad

  H.e.j. Res. Inst. Of Chemistry International Center For Chemical Sciences Univ. Of Karachi

• Tsamo Etienne

  Department Of Organic Chemistry Faculty Of Science University Of Yaounde 1

• Tsamo Etienne

  Departement De Chimie Organique Universite De Yaounde I

• Ngouela Silvere

  Department Of Organic Chemistry Faculty Of Science University Of Yaounde 1

• Ngouela Silvere

  カメルーン

• Choudhary M

  Univ. Karachi Karachi Pak

• NDJAKOU LENTA

  Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University

• DEVKOTA Krishna

  Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University

• FEKAM BOYOM

  Department of Biochemistry, Faculty of Science, University of Yaounde 1

• NAZ Quamar

  H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, U

• ROSENTHAL Philip

  Division of Infectious Diseases, Department of Medicine, University of California

• SEWALD Norbert

  Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University

• Rosenthal Philip

  Division Of Infectious Diseases Department Of Medicine University Of California

• Devkota Krishna

  Department Of Chemistry Organic And Bioorganic Chemistry Bielefeld University:institute Of Forestry

• Choudhary Muhammad

  International Centre For Chemical And Biological Sciences Hej Res. Inst. Of Chemistry Univ. Of Karac

• Naz Qamar

  H.e.j. Research Institute Of Chemistry International Center For Chemical And Biological Sciences Uni

• Fekam Boyom

  Department Of Biochemistry Faculty Of Science University Of Yaounde 1

• Ndjakou Lenta

  Department Of Chemistry Organic And Bioorganic Chemistry Bielefeld University:department Of Chemistr

• Sewald Norbert

  Department Of Chemistry Organic And Bioorganic Chemistry Bielefeld University

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