Microbial Hydroxylation of Pregnenolone Derivatives
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概要
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Pregnenolone (1) and pregnenolone acetate (2) were incubated with the fungi Cunninghamella elegans, Rhizopus stolonifer and Gibberella fujikuroi. Incubation of 1 with C. elegans yielded metabolites, 3β, 7β, 11α-trihy-droxypreg-5-en-20-one (3), 3β, 6α, 11α, 12β, 15β-pentahydroxypreg-4-en-20-one (4) and 3β, 6β, 11α-trihydroxypreg-4-en-20-one (5), while incubation with G. fujikuroi yielded two known metabolites, 3β, 7β-dihydroxypregn-5-en-20-one (6) and 6β, 15β-dihydroxypreg-4-ene-3, 20-dione (7). Metabolites 4 and 5 were found to be new. Fermentation of 2 by C. elegans yielded four known oxidative metabolites, 1, androsta-1, 4-diene-3, 17-dione (8), 6β, 15β-dihydroxyandrost-4-ene-3, 17-dione (9) and 11α, 15β-dihydroxypreg-4-ene-3, 20-dione (10). Fermentation of 2 with R. stolonifer yielded two known metabolites, 11α-hydroxypreg-4-ene-3, 20-dione (11) and 7. Compounds 1-11 were screened for their cholinesterase inhibitory activity in a mechanism-based assay.
- 2005-11-01
著者
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CHOUDHARY Muhammad
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Ka
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BATOOL Iffat
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Ka
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SHAH Syed
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Ka
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NAWAZ Sarfraz
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Ka
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RAHMAN ATTA
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Ka
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Choudhary Muhammad
H.e.j. Res. Inst. Of Chemistry International Center For Chemical And Biological Sciences Univ. Of Ka
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Rahman Atta-ur
International Center For Chemical Sciences H.e.j.research Institute Of Chemistry University Of Karac
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Nawaz Sarfraz
H.e.j. Research Institute Of Chemistry International Center For Chemical Sciences University Of Kara
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Atta-ur-rahman Atta-ur-rahman
H. E. J. Research Institute Of Chemistry International Center For Chemical Sciences University Of Ka
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Shah Syed
H.e.j. Res. Inst. Of Chemistry International Center For Chemical Sciences Univ. Of Karachi
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Batool Iffat
H.e.j. Research Institute Of Chemistry International Center For Chemical Sciences University Of Kara
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Choudhary Muhammad
H.e.j. Research Institute Of Chemistry International Center For Chemical Sciences University Of Kara
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