Isolation of Onosmins A and B, Lipoxygenase Inhibitors from Onosma hispida
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概要
- 論文の詳細を見る
Onosmins A (1) and B (2), lipoxygenase inhibitors, have been isolated from Onosma hispida. Their structures were established as 2-[(4-methylbenzyl)amino]benzoic acid (1) and methyl 2-[(4-methylbenzyl)amino]benzoate (2) through spectroscopic studies, including 2D-NMR. The known compounds apigenin (3), 6, 4'-dimethoxy-3, 5, 7-trihydroxyflavone (4), 6, 7-dimethoxy-3, 5, 4'-trihydroxyflavone (5) and apigenin 7-O-β-D-glucoside (6) are also reported for the first time from this species. Compounds (1) and (2) inhibited lipoxygenase (LOX, EC 1.13.11.12) enzyme in a concentration-dependent fashion with IC_<50> values of 24.0 and 36.2μm, respectively. Lineweaver-Burk as well as Dixon plots and their secondary replots indicated that the nature of inhibition was purely a non-competitive type, with K_i values 22.0μm and 31.1, respectively.
- 社団法人日本薬学会の論文
- 2005-08-01
著者
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CHOUDHARY Muhammad
International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of
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Choudhary M
International Center For Chemical Sciences H.e.j. Research Institute Of Chemistry University Of Kara
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Choudhary Muhammad
H.e.j. Res. Inst. Of Chemistry International Center For Chemical And Biological Sciences Univ. Of Ka
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Choudhary Muhammad
H.e.j. Research Institute Of Chemistry. International Centre For Chemical Sciences University Of Kar
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Choudhary Muhammad
H.e.j. Res. Inst. Of Chemistry International Center For Chemical Sciences Univ. Of Karachi
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Choudhary Muhammad
H. E. J. Research Institute Of Chemistry International Center For Chemical Sciences University Of Ka
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Choudhary Muhammad
H.e.j. Research Institute Of Chemistry International Center For Chemical Sciences University Of Kara
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MALIK Abdul
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Ka
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NAWAZ Sarfraz
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Ka
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Nawaz S
International Centre For Chemical Sciences H. E. J. Research Institute Of Chemistry University Of Ka
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Nawaz Sarfraz
International Center For Chemical Sciences H. E. J. Research Institute Of Chemistry University Of Ka
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Nawaz Sarfraz
パキスタン
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Choudhary M
Univ. Karachi Karachi Pak
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Malik A
International Centre For Chemical And Biological Sciences Hej Res. Inst. Of Chemistry Univ. Of Karac
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AFZA Nighat
Pharmaceutical Research Center, PCSIR Karachi Laboratories Complex
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AHMAD Ijaz
International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karac
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FATIMA Itrat
International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karac
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KHAN Sher
International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karac
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AHMAD Manzoor
International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karac
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Khan Sher
International Centre For Chemical Sciences H. E. J. Research Institute Of Chemistry University Of Ka
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Ahmad Ijaz
Univ. Karachi Karachi Pak
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Afza N
Pharmaceutical Research Center Pcsir Laboratories Karachi Complex
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Malik Abdul
International Centre Of Chemical Sciences Hej Research Institute Of Chemistry University Of Karachi
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Malik Abdul
International Centre For Chemical And Biological Sciences Hej Research Institute Of Chemistry Univer
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Fatima Itrat
Univ. Karachi Karachi Pak
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Ahmad Manzoor
International Center For Chemical Sciences Hej Research Institute Of Chemistry University Of Karachi
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Choudhary Muhammad
International Centre For Chemical And Biological Sciences Hej Res. Inst. Of Chemistry Univ. Of Karac
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Choudhary Muhammad
International Center For Chemical Sciences H.e.j. Res. Inst. Of Chemistry Univ. Of Karachi
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Fatima Itrat
International Center For Chemical Sciences Hej Research Institute Of Chemistry University Of Karachi
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Afza Nighat
Pharmaceutical Research Center Pcsir Laboratories Karachi Complex
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Choudhary Muhammad
International Center For Chemical Sciences H. E. J Research Institute Of Chemistry University Of Kar
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KHAN Sher
International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
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Malik Abdul
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
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