Cholinesterase Inhibiting and Antiplasmodial Steroidal Alkaloids from Sarcococca hookeriana

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概要

• 論文の詳細を見る

• Bioguided phytochemical investigation of Sarcococca hookeriana with respect to the cholinesterase enzyme inhibitory assay yielded two new pregnane-type steriodal alkaloids hookerianamide H (1) and hookerianamide I (2), along with three known alkaloids N_a-methylepipachysamine D (3), sarcovagine C (4) and dictyophlebine (5). Their structures were determined with the aid of extensive spectroscopic analysis. All compounds showed good inhibitory activities against the enzymes acetylcholinesterase (IC_<50> 2.9-34.1μM) and butyrylcholinesterase (IC_<50> 0.3-3.6μM). These compounds also showed moderate antiplasmodial activity (IC_<50> 2.4-10.3μM) against the Plasmodium falciparum chloroquine resistant W2 strain.

• 社団法人日本薬学会の論文
• 2007-09-01

著者

• CHOUDHARY Muhammad

  H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Ka

• Choudhary M

  International Center For Chemical Sciences H.e.j. Research Institute Of Chemistry University Of Kara

• Choudhary Muhammad

  H.e.j. Res. Inst. Of Chemistry International Center For Chemical And Biological Sciences Univ. Of Ka

• Choudhary Muhammad

  H.e.j. Research Institute Of Chemistry International Center For Chemical And Biological Sciences Uni

• Choudhary Muhammad

  H.e.j. Res. Inst. Of Chemistry International Center For Chemical Sciences Univ. Of Karachi

• Choudhary M

  Univ. Karachi Karachi Pak

• DEVKOTA Krishna

  Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University

• ROSENTHAL Philip

  Division of Infectious Diseases, Department of Medicine, University of California

• SEWALD Norbert

  Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University

• LENTA Bruno

  Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University

• NAZ Qamar

  H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, U

• FEKAM Fabrice

  Department of Biochemistry, Faculty of Science, University of Yaounde I

• Rosenthal Philip

  Division Of Infectious Diseases Department Of Medicine University Of California

• Lenta Bruno

  Department Of Chemistry Organic And Bioorganic Chemistry Bielefeld University

• Devkota Krishna

  Department Of Chemistry Organic And Bioorganic Chemistry Bielefeld University:institute Of Forestry

• Choudhary Muhammad

  International Centre For Chemical And Biological Sciences Hej Res. Inst. Of Chemistry Univ. Of Karac

• Naz Qamar

  H.e.j. Research Institute Of Chemistry International Center For Chemical And Biological Sciences Uni

• Boyom Fabrice

  Dep. Of Biochemistry Fac. Of Sci. Univ. Of Yaounde

• Fekam Fabrice

  Department Of Biochemistry Faculty Of Science University Of Yaounde 1

• Sewald Norbert

  Department Of Chemistry Organic And Bioorganic Chemistry Bielefeld University

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