Anti-plasmodial Activity of Some Constituents of the Root Bark of Harungana madagascariensis LAM.(Hypericaceae)
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概要
- 論文の詳細を見る
Bazouanthrone (1), a new anthrone derivative, has been isolated from the root bark of Harungana madagascariensis, together with known compounds, feruginin A (2), harunganin (3), harunganol A (4), harunganol B (5), friedelan-3-one (6) and betulinic acid (7). The structure of the compound (1) was assigned as 3, 5, 8, 9-tetrahydroxy-2, 4, 4-tri-(3, 3-dimethylallyl)-6-methyl-1-(4H)-anthracenone, by means of spectroscopic analysis. The antiplasmodial activity of the isolated compounds was evaluated in culture against W2 strain of Plasmodium falciparum. All the compounds were found to be active against the Plasmodium parasites with bazouanthrone (1) showing particular potency (IC_<50>=1.80μм).
- 公益社団法人日本薬学会の論文
- 2007-03-01
著者
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Tsamo Etienne
Department Of Organic Chemistry Faculty Of Science University Of Yaounde 1
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Tsamo Etienne
Departement De Chimie Organique Universite De Yaounde I
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Ngouela Silvere
Department Of Organic Chemistry Faculty Of Science University Of Yaounde 1
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Ngouela Silvere
カメルーン
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NDJAKOU LENTA
Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University
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FEKAM BOYOM
Department of Biochemistry, Faculty of Science, University of Yaounde 1
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ROSENTHAL Philip
Division of Infectious Diseases, Department of Medicine, University of California
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Rosenthal Philip
Division Of Infectious Diseases Department Of Medicine University Of California
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GUT Jiri
Division of Infectious Diseases, Department of Medicine, University of California San Francisco
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TANTANGMO Ferdinand
Department of Organic Chemistry, Faculty of Science, University of Yaounde I
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FEUYA TCHOUYA
Department of Organic Chemistry, Faculty of Science, University of Yaounde I
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DONALD CONNOLLY
Department of Chemistry, The University
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Gut Jiri
Division Of Infectious Diseases Department Of Medicine University Of California San Francisco
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Fekam Boyom
Department Of Biochemistry Faculty Of Science University Of Yaounde 1
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Ndjakou Lenta
Department Of Chemistry Organic And Bioorganic Chemistry Bielefeld University:department Of Chemistr
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Feuya Tchouya
Department Of Organic Chemistry Faculty Of Science University Of Yaounde I
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Donald Connolly
Department Of Chemistry The University
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Tantangmo Ferdinand
Department Of Organic Chemistry Faculty Of Science University Of Yaounde I
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