Two New Antimicrobial Dimeric Compounds: Febrifuquinone, a Vismione-Anthraquinone Coupled Pigment and Adamabianthrone, from two Psorospermum Species

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概要

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• Febrifuquinone (1), a new vismione-anthraquinone coupled pigment and a new bianthrone named adamabianthrone (2), were isolated respectively, from the roots of Psorospermum febrifugum and from the bark of Psorospermum adamauense along with eight known compounds including: two bianthrones [(bianthrone A1 (3) and bianthrone A2b], one vismione [(vismione D (4)], one anthrone (3-geranyloxyemodin anthrone) and four anthraquinones [(1,8-dihydroxy-3-isoprenyloxy-6-methylanthraquinone, emodin (5), 3-geranyloxy-1,8-dihydroxy-6-methylanthraquinone and 2-geranyl-1,8-dihydroxy-6-methylanthraquinone]. Their structures were determined using modern spectroscopic methods including one and two dimensional-NMR techniques as well as MS. Compounds 1 and 2 showed significant antimicrobial activities against a wide range of bacteria and fungi.

著者

• Tsamo Etienne

  Departement De Chimie Organique Universite De Yaounde I

• Mkounga Pierre

  Department of Organic Chemistry, Faculty of Sciences, University of Yaounde I

• Nkengfack Augustin

  Department Of Organic Chemistry Faculty Of Science University Of Yaounde I

• Hultin Philip

  Department of Chemistry, Manitoba University

• Ndejouong Tchize

  Department of Biomolecular Chemistry, Leibniz Institute for Natural Products Research and Infection Biology

• Nkengfack Augustin

  Department of Organic Chemistry, TWAS Research Unit, Yaounde University I

• Tsaffack Maurice

  Department of Organic Chemistry, TWAS Research Unit, Yaounde University I

• Tsamo Etienne

  Department of Organic Chemistry, TWAS Research Unit, Yaounde University I

• Nguemeving Jean

  Department of Organic Chemistry, TWAS Research Unit, Yaounde University I

• Kuete Victor

  Department of Biochemistry, Dschang University

• Penlap Beng

  Department of Biochemistry, Yaounde University I

関連論文

• Newbouldiaquinone and Newbouldiamide : A New Naphthoquinone-Anthraquinone Coupled Pigment and a New Ceramide from Newbouldia laevis
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• α-Glucosidase Inhibitors from Garcinia brevipedicellata (Clusiaceae)
• Anti-plasmodial Activity of Some Constituents of the Root Bark of Harungana madagascariensis LAM.(Hypericaceae)
• Two New Antimicrobial Dimeric Compounds: Febrifuquinone, a Vismione-Anthraquinone Coupled Pigment and Adamabianthrone, from two Psorospermum Species
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