Rubescins A, B and C: New Havanensin Type Limonoids from Root Bark of Trichilia rubescens (Meliaceae)

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概要

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• Three new limonoids, rubescins A–C (1–3), and three known compounds including, havanensin type limonoid TS3 (4), β-sitosterol, and stigmasterol were isolated from the root bark of Trichilia rubescens. Their structures were elucidated by means of extensive spectroscopic analyses, particularly one dimensional (1D)- and 2D-NMR techniques in conjunction with mass spectrometry. Rubescins A–C (1–3) and limonoid TS3 (4) were evaluated for their protective effects against oxidative stress induced in HC-04 cells by H2O2. Compound (1) showed strong inhibitory effects on lactase dehydrogenase (LDH) leakage, being as active (IC50 value of 0.0026 µ<span style="font-variant: small-caps;">M</span>) as the positive control quercetin (IC50 value of 0.0030 µ<span style="font-variant: small-caps;">M</span>).

• 公益社団法人 日本薬学会の論文

著者

• Mkounga Pierre

  Department of Organic Chemistry, Faculty of Sciences, University of Yaounde I

• Nkengfack Augustin

  Department Of Organic Chemistry Faculty Of Science University Of Yaounde I

• Hultin Philip

  Department of Chemistry, Manitoba University

• Mkounga Pierre

  Department of Organic Chemistry, University of Yaounde I

• Kirk Marat

  Department of Chemistry, University of Manitoba

• Tsamo Tontsa

  Department of Organic Chemistry, University of Yaounde I

• Njayou Fréderic

  Department of Biochemistry, University of Yaounde I

• Manautou José

  Department of Pharmaceutical Sciences, University of Connecticut

• Hultin Philip

  Department of Chemistry, University of Manitoba

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• Rubescins A, B and C: New Havanensin Type Limonoids from Root Bark of Trichilia rubescens (Meliaceae)

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