Prenylated Xanthone Derivatives with Antiplasmodial Activity from Allanblackia monticola STANER L.C.

スポンサーリンク

概要

• 論文の詳細を見る

• Further study of the methanol extract of the stem bark of Allanblackia monticola STANER L.C. resulted in the isolation of a new prenylated xanthenedione, designated allanxanthone C, together with the five known xanthones, garciniafuran, tovophyllin A, rubraxanthone, norcowanin and mangostin and one saponin, stigmasterol-3-O-β-D-glucopyranoside. The structure of the new compound was established by detailed spectroscopic analysis to be 1,2-dihydro-3,6,8-trihydroxy-1,1,7-tri(3-methylbut-2-enyl)xanthen-2,9-dione (3-hydroxyapetalinone C). The methanol extract and pure compounds were tested on two strains of Plasmodium falciparum, F32 (chloroquine sensitive) and FcM29 (chloroquine resistant). The IC_<50> values obtained ranged from 0.6 to 8.9μg/ml. Their cytotoxicity was estimated on human melanoma cells (A375) and the cytotoxicity/antiplasmodial ratio was found to be between 15.45 and 30.46. The antimicrobial activities against a range of microorganisms of the crude extract and some of these compounds are also reported.

• 公益社団法人日本薬学会の論文
• 2006-01-01

著者

• NKENGFACK Augustin

  Department of Organic Chemistry, Yaounde University

• Meyer Michele

  Laboratoire De Chimie Et Biochimie Des Substances Naturelles

• Fomum Zacharias

  Department Of Organic Chemistry Faculty Of Science University Of Yaounde I

• Azebaze Anatole

  Department Of Chemistry Faculty Of Science University Of Douala

• VALENTIN Alexis

  Pharmacochimie des Substances Naturelles et Pharmacophores Redox

• NGUEMFO Edwige

  Department of Animals Biology and Physiology, Faculty of Science, University of Yaounde I

• Fomum Zacharias

  Fac. Of Sci. Univ. Of Yaounde I

• Nguemfo Edwige

  Department Of Animals Biology And Physiology Faculty Of Science University Of Yaounde I

• Nkengfack Augustin

  Dep. Of Organic Chemistry Fac. Of Sci. Twas Res. Unit Of Univ. Of Yaounde I

• Nkengfack Augustin

  Department Of Organic Chemistry Faculty Of Science University Of Yaounde I

関連論文

• Newbouldiaquinone and Newbouldiamide : A New Naphthoquinone-Anthraquinone Coupled Pigment and a New Ceramide from Newbouldia laevis
• Ceramide and Cerebroside from the Stem Bark of Ficus mucuso (Moraceae)
• Two New Antimicrobial Dimeric Compounds: Febrifuquinone, a Vismione-Anthraquinone Coupled Pigment and Adamabianthrone, from two Psorospermum Species
• Alkaloids from the Stem Bark of Turraeanthus africanus (Meliaceae)
• Prenylated Xanthone Derivatives with Antiplasmodial Activity from Allanblackia monticola STANER L.C.
• Estrogenic effects of a methanol extract of the fruit of Brenania brieyi de Wild (Rubiaceae)
• Afzeliixanthones A and B, Two New Prenylated Xanthones from Garcinia afzelii ENGL. (Guttiferae)
• Rubescins A, B and C: New Havanensin Type Limonoids from Root Bark of Trichilia rubescens (Meliaceae)

スポンサーリンク