Tyrosinase Inhibitors from Rhododendron collettianum and Their Structure-Activity Relationship (SAR) Studies

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概要

• 論文の詳細を見る

• A new coumarinolignoid 8'-epi-cleomiscosin A (1) together with the new glycoside 8-O-β-_D-glucopyranosyl-6-hydroxy-2-methyl-4H-1-benzopyrane-4-one (2) have been isolated from the aerial parts of Rhododendron collettianum and their structures determined on the basis of spectroscopic evidences. Tyrosinase inhibition study of these compounds and their structure-activity relationship (SAR) were also investigated. The compounds exhibited potent to mild inhibition activity against the enzyme. Especially, the compound 1 showed strong inhibition (IC_<50>=1.33μM) against the enzyme tyrosinase, as compared to the standard tyrosinase inhibitors kojic acid (IC_<50>=16.67μM) and _L-mimosine (IC_<50>=3.68μM), indicating its potential used for the treatment of hyperpigmentation associated with the high production of melanocytes.

• 社団法人日本薬学会の論文
• 2004-12-01

著者

• Choudhary M

  International Center For Chemical Sciences H.e.j. Research Institute Of Chemistry University Of Kara

• Choudhary Muhammad

  H.e.j. Res. Inst. Of Chemistry International Center For Chemical And Biological Sciences Univ. Of Ka

• Choudhary Muhammad

  H.e.j. Research Institute Of Chemistry. International Centre For Chemical Sciences University Of Kar

• Choudhary Muhammad

  H.e.j. Res. Inst. Of Chemistry International Center For Chemical Sciences Univ. Of Karachi

• Choudhary Muhammad

  H. E. J. Research Institute Of Chemistry International Center For Chemical Sciences University Of Ka

• Choudhary Muhammad

  H.e.j. Research Institute Of Chemistry International Center For Chemical Sciences University Of Kara

• Hussain Javid

  International Center For Chemical Sciences H. E. J. Research Institute Of Chemistry University Of Ka

• Choudhary M

  Univ. Karachi Karachi Pak

• Ahmad V

  H.e.j Research Institute Of Chemistry International Center For Chemical And Biological Sciences Univ

• Khan Mahmud

  H. E. J. Research Institute Of Chemistry University Of Karachi

• Ahmad Viqar

  H. E. J. Research Institute Of Chemistry Faculty Of Pharmacy University Of Karachi

• Ullah Farman

  International Center For Chemical Sciences H. E. J. Research Institute Of Chemistry University Of Ka

• Farooq Umar

  Department Of Environmental Sciences Comsats Institute Of Information Technology

• ULLAH Farman

  H. E. J. Research Institute of Chemistry, University of Karachi

• HUSSAIN Javid

  H. E. J. Research Institute of Chemistry, University of Karachi

• FAROOQ Umar

  H. E. J. Research Institute of Chemistry, University of Karachi

• ZUBAIR Muhammad

  H. E. J. Research Institute of Chemistry, University of Karachi

• Choudhary Muhammad

  International Centre For Chemical And Biological Sciences Hej Res. Inst. Of Chemistry Univ. Of Karac

• Choudhary Muhammad

  International Center For Chemical Sciences H.e.j. Res. Inst. Of Chemistry Univ. Of Karachi

• Zubair Muhammad

  H. E. J. Research Institute Of Chemistry University Of Karachi

• Choudhary Muhammad

  H. E. J Research Institute Of Chemistry International Center For Chemical Sciences University Of Kar

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