β-N-Cyanoethyl Acyl Hydrazide Derivatives : A New Class of β-Glucuronidase Inhibitors
スポンサーリンク
概要
- 論文の詳細を見る
Eight new β-N-substituted acyl hydrazides along with their corresponding acyl derivatives were synthesized and screened for in vitro β-glucuronidase inhibition and found to be active against the enzyme. All of these compounds were found to be noncompetitive inhibitors except for N'-(2-cyanoethyl)-4-hydroxy benzohydrazide (10), which was found to be an uncompetitive inhibitor. Structure-activity relationship studies indicated that the ben-zyloxy group present in compounds 12 and 13 is responsible for the β-glucuronidase inhibition activity.
- 2002-11-01
著者
-
CHOUDHARY Muhammad
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Ka
-
KHAN Khalid
H.E.J. Research Institute of Chemistry. International Centre for Chemical Sciences, University of Ka
-
SHUJAAT Shahida
H.E.J. Research Institute of Chemistry. International Centre for Chemical Sciences, University of Ka
-
RAHAT Shagufta
H.E.J. Research Institute of Chemistry. International Centre for Chemical Sciences, University of Ka
-
HAYAT Safdar
H.E.J. Research Institute of Chemistry. International Centre for Chemical Sciences, University of Ka
-
Choudhary M
International Center For Chemical Sciences H.e.j. Research Institute Of Chemistry University Of Kara
-
Choudhary Muhammad
H.e.j. Res. Inst. Of Chemistry International Center For Chemical And Biological Sciences Univ. Of Ka
-
Choudhary Muhammad
H.e.j. Research Institute Of Chemistry. International Centre For Chemical Sciences University Of Kar
-
Choudhary Muhammad
H.e.j. Res. Inst. Of Chemistry International Center For Chemical Sciences Univ. Of Karachi
-
Choudhary Muhammad
H. E. J. Research Institute Of Chemistry International Center For Chemical Sciences University Of Ka
-
Choudhary Muhammad
H.e.j. Research Institute Of Chemistry International Center For Chemical Sciences University Of Kara
-
Khan Khalid
H.e.j. Research Institute Of Chemistry. International Centre For Chemical Sciences University Of Kar
-
Choudhary M
Univ. Karachi Karachi Pak
-
SHUJAAT Shahida
International Centre for Chemical Sciences HEJ Research Institute of Chemistry University of Karachi
-
Rahman Atta-ur
International Center For Chemical Sciences H.e.j.research Institute Of Chemistry University Of Karac
-
Rahman Atta-ur
H. E. J Research Institute Of Chemistry International Center For Chemical Sciences University Of Kar
-
Hayat S
H.e.j. Research Institute Of Chemistry. International Centre For Chemical Sciences University Of Kar
-
Hayat Safdar
International Center For Chemical Sciences H.e.j.research Institute Of Chemistry University Of Karac
-
Rahat Shagufta
H.e.j. Research Institute Of Chemistry. International Centre For Chemical Sciences University Of Kar
-
Hayat Safdar
H.e.j. Research Institute Of Chemistry. International Centre For Chemical Sciences University Of Kar
-
Choudhary Muhammad
International Centre For Chemical And Biological Sciences Hej Res. Inst. Of Chemistry Univ. Of Karac
-
Shujaat Shahida
H.e.j. Research Institute Of Chemistry. International Centre For Chemical Sciences University Of Kar
-
Choudhary Muhammad
International Center For Chemical Sciences H.e.j. Res. Inst. Of Chemistry Univ. Of Karachi
-
Atta-ur-rahman Atta-ur-rahman
H. E. J. Research Institute Of Chemistry International Center For Chemical Sciences University Of Ka
関連論文
- Biotransformation of Physalin H and Leishmanicidal Activity of Its Transformed Products
- Phenyl Polypropanoids from Lindelofia stylosa
- Microbial Hydroxylation of Pregnenolone Derivatives
- Lipoxygenase Inhibiting Constituents from Indigofera hetrantha
- Cholinesterase Inhibiting Withanolides from Withania somnifera
- Paeonins A and B, Lipoxygenase Inhibiting Monoterpene Galactosides from Paeonia emodi
- β-N-Cyanoethyl Acyl Hydrazide Derivatives : A New Class of β-Glucuronidase Inhibitors
- New Cholinesterase Inhibiting Steroidal Alkaloids from the Leaves of Sarcococca coriacea of Nepalese Origin
- Two New Cinnamic Acid Esters from Marine Brown Alga Spatoglossum variabile
- Isoflavonoid Glycosides from the Rhizomes of Iris germanica
- New Steroidal Alkaloids from Fritillaria imperialis and Their Cholinesterase Inhibiting Activities
- Two New Aurones from Marine Brown Alga Spatoglossum variabile
- A Novel β-Glucuronidase Inhibiting Triterpenoid from Paeonia emodi
- Hyperinols A and B, Chymotrypsin Inhibiting Triterpenes from Hypericum oblongifolium
- Halosterols A and B, Chymotrypsin Inhibitory Sterols from Haloxylon recurvum
- Chymotrypsin Inhibitory Triterpenoids from Silybum marianum
- Isolation of Onosmins A and B, Lipoxygenase Inhibitors from Onosma hispida
- Haloxylines A and B, Antifungal and Cholinesterase Inhibiting Piperidine Alkaloids from Haloxylon salicornicum
- Tyrosinase-Inhibitory Long-Chain Esters from Amberboa ramosa
- Enzymes Inhibiting Lignans from Vitex negundo
- Cholinesterase Inhibitory Constituents from Onosma hispida
- α-Glucosidase Inhibitory Constituents from Cuscuta reflexa
- First Natural Urease Inhibitor from Euphorbia decipiens
- Enzyme Inhibitory Constituents from Duranta repens
- Anti-plasmodial and Cholinesterase Inhibiting Activities of some Constituents of Psorospermum glaberrimum
- Cholinesterase Inhibiting and Antiplasmodial Steroidal Alkaloids from Sarcococca hookeriana
- Microbial Transformation of the Steroidal Alkaloid Dictyophlebine by Rhizopus stolonifer
- Three New Cholinesterase-Inhibiting cis-Clerodane Diterpenoids from Otostegia limbata
- Tyrosinase Inhibitors from Rhododendron collettianum and Their Structure-Activity Relationship (SAR) Studies
- Two New Diterpenoids from Ballota limbata
- Botanical origin of Indian celery seed (fruit)
- α-Glucosidase Inhibitory Constituents from Duranta repens
- タイトル無し
- α-Glucosidase Inhibitors from Millettia conraui
- A New Ferulic Acid Ester and Other Constituents from Tamarix nilotica Leaves