New Cholinesterase Inhibiting Steroidal Alkaloids from the Leaves of Sarcococca coriacea of Nepalese Origin

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概要

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• From the leaves of Sarcococca coriacea two new steroidal alkaloids, epoxynepapakistamine-A [(20S)-20-(N-methylamino)-3β-(tigloylamino)-5α-pregna-16α,17α-epoxy-2β,4β-di-O-acetate] (1), and epoxysarcovagenine-D [(20S)-20-(N-methylamino)-3β-(tigloylamino)-5α-pregna-2-en-16α,17α-epoxy-4-one] (2), and two known compounds funtumafrine C [(20S)-20-(N,N-dimethylamino)-5α-pregna-3-one] (3) and N-methylfuntumine (4) were isolated. Their structures were elucidated on the basis of their spectral properties. The compounds 1, 3 and 4 were found to have cholinesterase inhibitory activity when tested for the inhibition of electric eel acetylcholinesterase and horse serum butyrylcholinesterase. They inhibited both enzymes in a concentration dependent fashion.

• 2002-11-01

著者

• Choudhary Muhammad

  H. E. J. Research Institute Of Chemistry International Center For Chemical Sciences University Of Ka

• KALAUNI Surya

  Central Department of Chemistry, Tribhuvan University

• KHALID Asaad

  H. E. J Research Institute of Chemistry International Center for Chemical Sciences, University of Ka

• MANANDHAR Mangala

  Central Department of Chemistry, Tribhuvan University

• SHAHEEN Farzana

  H. E. J Research Institute of Chemistry International Center for Chemical Sciences, University of Ka

• RAHMAN ATTA-UR

  H. E. J Research Institute of Chemistry International Center for Chemical Sciences, University of Ka

• GEWALI Mohan

  Central Department of Chemistry, Tribhuvan University

• Manandhar Mangala

  Central Department Of Chemistry Tribhuvan University

• Manandhar Mangala

  ネパール

• Rahman Atta-ur

  International Center For Chemical Sciences H.e.j.research Institute Of Chemistry University Of Karac

• Rahman Atta-ur

  H. E. J Research Institute Of Chemistry International Center For Chemical Sciences University Of Kar

• Kalauni Surya

  Central Department Of Chemistry Tribhuvan University

• Gewali Mohan

  Central Department Of Chemistry Tribhuvan University

• Khalid Asaad

  H. E. J Research Institute Of Chemistry International Center For Chemical Sciences University Of Kar

• Shaheen Farzana

  H. E. J Research Institute Of Chemistry International Center For Chemical Sciences University Of Kar

• Choudhary Muhammad

  H. E. J Research Institute Of Chemistry International Center For Chemical Sciences University Of Kar

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