Enzyme Inhibitory Constituents from Duranta repens
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概要
- 論文の詳細を見る
Isoprenylated flavonoids 5,7-dihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-3,6,4'-trimethoxyflavone (1), 3,7-dihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-5,6,4'-trimethoxyfanvone (2) and an isoprenylated acetophenone derivative (3) have been isolated from Duranta repens along with known compounds, 5-hydroxy-3,6,7,4'-tetra-methoxyflavone (4), rosenonolactone (5), 6,7-dimethoxycoumarin (6), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (7) and 5α,8α-epidioxyergosta-6,9(11),22-trien-3β-ol (8), isolated for the first time from this species. Their structures and the relative configuration were determined by spectroscopic methods ( ^1H- and ^<13>C-NMR, IR, UV and MS) and two-dimensional (2D)-NMR experiments. The compounds 1-5 showed inhibitory activity against prolyl endopeptidase while 4 and 5 were also active against thrombin.
- 社団法人日本薬学会の論文
- 2002-04-01
著者
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Choudhary M
International Center For Chemical Sciences H.e.j. Research Institute Of Chemistry University Of Kara
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Choudhary Muhammad
H.e.j. Res. Inst. Of Chemistry International Center For Chemical And Biological Sciences Univ. Of Ka
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Choudhary Muhammad
H.e.j. Research Institute Of Chemistry. International Centre For Chemical Sciences University Of Kar
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Choudhary Muhammad
H.e.j. Res. Inst. Of Chemistry International Center For Chemical Sciences Univ. Of Karachi
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Choudhary Muhammad
H. E. J. Research Institute Of Chemistry International Center For Chemical Sciences University Of Ka
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Choudhary Muhammad
H.e.j. Research Institute Of Chemistry International Center For Chemical Sciences University Of Kara
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ANIS Itrat
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Ka
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MALIK Abdul
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Ka
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Anis Itrat
International Centre For Chemical Sciences H. E. J. Research Institute Of Chemistry University Of Ka
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Anis Itrat
International Centre Of Chemical Sciences Hej Research Institute Of Chemistry University Of Karachi
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Anis Itrat
International Center For Chemical Sciences H.e.j.research Institute Of Chemistrv University Of Karac
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Anis Itrat
パキスタン
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Anis Itrat
International Center For Chemical Science H. E. J. Research Institute Of Chemistry University Of Kar
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Yasin Amsha
International Center Of Chemical Sciences Hej Research Institute Of Chemistry University Of Karachi
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Choudhary M
Univ. Karachi Karachi Pak
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Ahmed Shakil
H. E. J. Research Institute Of Chemistry International Center For Chemical Sciences University Of Ka
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Ahmed Shakil
H.e.j. Res. Inst. Of Chemistry International Center For Chemical Sciences Univ. Of Karachi
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Malik A
International Centre For Chemical And Biological Sciences Hej Res. Inst. Of Chemistry Univ. Of Karac
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AHMED Saeed
International Center for Chemical Sciences, H.E.J.Research Institute of Chemistrv, University of Kar
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CHOUDARY M.
International Center of Chemical Sciences, HEJ Research Institute of Chemistry, University of Karach
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Ahmed S
Univ. Karachi Karachi Pak
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Malik Abdul
International Centre Of Chemical Sciences Hej Research Institute Of Chemistry University Of Karachi
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Malik Abdul
International Centre For Chemical And Biological Sciences Hej Research Institute Of Chemistry Univer
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Choudhary Muhammad
International Centre For Chemical And Biological Sciences Hej Res. Inst. Of Chemistry Univ. Of Karac
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Ahmed Saeed
International Center For Chemical Sciences H.e.j.research Institute Of Chemistrv University Of Karac
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Choudhary Muhammad
International Center For Chemical Sciences H.e.j. Res. Inst. Of Chemistry Univ. Of Karachi
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Malik Abdul
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
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