A Plasmidic Class 1 Integron from Five Pseudomonas aeruginosa Clinical Strains Harbored aacA4 and Nonsense-mutated cmlA1 Gene Cassettes
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概要
- 論文の詳細を見る
Five strains of multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) were isolated from inpatients at a local hospital in China. The most frequent resistance was to cefoperazone, ciprofloxacin, ceftriaxone, cefotaxime, gentamicin, piperacillin, trimethoprim sulfamethoxazole, and tobramycin. These strains were found to contain the class 1 integron, in which the 2360-bp gene cassettes were flanked by 5'- and 3'-conserved segments. Sequence analysis revealed that the gene cassettes contained aacA4 and cmlA1 genes; however, the latter gene had a nonsense mutation resulting in the production of a truncated protein. To the best of our knowledge, this is the first report of a nonsense mutation in the cmlA1 gene. Moreover, the P. aeruginosa strains showed identical profiles in pulsed-field gel electrophoresis, suggesting that they were derived from the same clone. These results emphasize the importance of controlling the spread of multidrug-resistant pathogens in hospitals.
- 社団法人日本薬学会の論文
- 2007-12-01
著者
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Yan He
College of Light Industry and Food Sciences, South China University of Technology
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Li Lin
College of Light Industry and Food Sciences, South China University of Technology
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Shi Lei
College of Light Industry and Food Sciences, South China University of Technology
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Miyoshi Shin-ichi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Shi Lei
Coll. Of Light Ind. And Food Sciences South China Univ. Of Technol.
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Shi L
Univ. Sci. And Technol. China Hefei Chn
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MIYOSHI Shin-ichi
Faculty of Pharmaceutical Sciences, Okayama University
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YANG Liansheng
College of Light Industry and Food Sciences, South China University of Technology
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YAMASAKI Shinji
College of Light Industry and Food Sciences, South China University of Technology
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Li Xinhui
School of Biological Science and Bioengineering, South China University of Technology
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Cao Yicheng
School of Biological Science and Bioengineering, South China University of Technology
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Yamasaki Shinji
College Of Light Industry And Food Sciences South China University Of Technology
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Miyoshi Shin-ichi
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Li Lin
Department Of Crystalline Materials Science Faculty Of Engineering Nagoya University
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Li Xinhui
School Of Biological Science And Bioengineering South China University Of Technology
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Cao Yicheng
School Of Biological Science And Bioengineering South China University Of Technology
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Yang Liansheng
College Of Light Industry And Food Sciences South China University Of Technology
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Miyoshi S
Faculty Of Pharmaceutical Sciences Okayama University
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Li Lin
Institute For Occupational & Environment Medicine Jining Medical College
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Li Lin
College Of Light Industry And Food Sciences South China University Of Technology
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LI Lin
College of Biological Science and Technology, Beijing Forestry University
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