Defensive Effects of Human Antimicrobial Peptide α-Defensins against Enterococcus faecalis
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概要
- 論文の詳細を見る
Cationic and amphiphilic antimicrobial peptides (AMPs) such as α-defensins and cathelicidins are factors related to innate immunity. In the present study, we examined the protective effects of two AMPs, human neutrophil peptide-3 and α-defensin-5, against the opportunistic pathogen Enterococcus faecalis (E. faecalis). The α-defensins had dose-dependent bactericidal activity, whereas they showed no synergistic effect on the antimicrobial actions of antibiotics. Although AMPs often neutralize bacterial bioactive products, neither α-defensin reduced the proteolytic activity of GelE, a toxic protease from E. faecalis. On the other hand, the α-defensins were found to be fairly stable even in the presence of excess amounts of GelE. These results indicate that α-defensins may be defensive factors against E. faecalis in humans.
- 公益社団法人 日本薬学会の論文
著者
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Miyoshi Shin-ichi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Maehara Yoko
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Maehara Yoko
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Univ.
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Miyoshi Shin-ichi
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Nakao Hiroshi
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Koyama Kenta
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Mizuno Tamaki
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Kashihara Minoru
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Mizuno Tamaki
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Univ.
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