Analysis of Genetic Determinants Involved in Multiresistance in Clinical Strains Isolated from Renal Transplantation Recipients in Guangzhou, China
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概要
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In the present study, we examined the antibiotic sensitivity of 19 bacterial strains [5 coagulase-negative Staphylococcus, 2 methicillin-resistant Staphylococcus aureus (S. aureus), 2 Enterococcus faecium (E. faecium), 5 Escherichia coli (E. coli), 3 Cedecea sp., 1 Klebsiella pneumoniae (K. pneumoniae), and 1 Burkholderia cepacia (B. cepacia)], which were isolated from renal transplantation patients using the Kirby-Bauer method. We also investigated the production of β-lactamase and extended-spectrum β-lactamase (ESBL), and the presence of the integrase gene (intIl) and resistance gene cassette. Among the 19 strains tested, all displayed severe multiresistance, and 12 strains produced β-lactamase, in which 6 strains were ESBL positive. Eleven strains were revealed to possess the class 1 integron; however, neither class 2 nor 3 was detected. Additionally, 3 drug resistance genes, aadA2, dfrA17, and aadA5, were found in some strains. The results indicate that the horizontal transfer of the β-lactamase gene and/or the class 1 integron may contribute significantly to the spread of multiresistant bacteria among renal transplantation patients.
- 2007-04-01
著者
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Li Lin
College of Light Industry and Food Sciences, South China University of Technology
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Shi Lei
College of Light Industry and Food Sciences, South China University of Technology
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Kou Yali
College of Food and Biological Engineering, South China University of Technology
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Miyoshi Shin-ichi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Shi Lei
Coll. Of Light Ind. And Food Sciences South China Univ. Of Technol.
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Shi L
Univ. Sci. And Technol. China Hefei Chn
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MIYOSHI Shin-ichi
Faculty of Pharmaceutical Sciences, Okayama University
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Kou Yali
College Of Food And Biological Engineering South China University Of Technology
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Miyoshi Shin-ichi
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Li Lin
Department Of Crystalline Materials Science Faculty Of Engineering Nagoya University
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Miyoshi S
Faculty Of Pharmaceutical Sciences Okayama University
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Li Lin
Institute For Occupational & Environment Medicine Jining Medical College
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Li Lin
College Of Light Industry And Food Sciences South China University Of Technology
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LI Lin
College of Biological Science and Technology, Beijing Forestry University
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