Cloning and Characterization of the ddc Homolog Encoding L-2,4-Diaminobutyrate Decarboxylase in Enterbacter aerogenes

スポンサーリンク

概要

• 論文の詳細を見る

• L-2,4-Diaminobutyrate decarboxylase (DABA DC) catalyzes the formation of 1,3-diaminopropane (DAP) from DABA. In the present study, the ddc gene encoding DABA DC from Enterobacter aerogenes ATCC 13048 was cloned and characterized. Determination of the nucleotide sequence revealed an open reading frame of 1470 bp encoding a 53659-Da protein of 490 amino acids, whose deduced NH_2-terminal sequence was identical to that of purified DABA DC from E. aerogenes. The deduced amino acid sequence was highly similar to those of Acinetobacter baumannii and Haemophilus influenzae DABA DCs encoded by the ddc genes. The lysine-307 of the E. aerogenes DABA DC was identified as the pyridoxal 5'-phosphate binding residue by site-directed mutagenesis. Furthermore, PCR analysis revealed the distribution of E. aerogenes ddc homologs in some other species of Enterobacteriaceae. Such a relatively wide occurrence of the ddc homologs implies biological singificance of DABA DC and its product DAP.

• 社団法人日本薬学会の論文
• 2000-05-01

著者

• Shinoda Sumio

  Faculty of Sciences, Okayama University of Science

• Yamamoto S

  Fukuoka Univ. Fukuoka Jpn

• SHINODA Sumio

  Laboratory of Environmental Hygine, Faculty of Pharmaceutical Sciences, Okayama University

• Tsuzuki Daisuke

  Laboratories of Health Chemistry, Okayama University

• MIYOSHI Shin-ichi

  Faculty of Pharmaceutical Sciences, Okayama University

• NARIMATSU Shizuo

  Faculty of Pharmaceutical Sciences, Okayama University

• YAMAMOTO Shigeo

  Faculty of Pharmaceutical Sciences, Okayama University

• MUTOH Nobuo

  Faculty of Pharmaceutical Sciences, Okayama University

• TSUZUKI Daisuke

  Faculty of Pharmaceutical Sciences, Okayama University

• IKAI Hisato

  Faculty of Pharmaceutical Sciences, Okayama University

• NAKAO Hiroshi

  Department of Infectious Diseases Research, National Children's Medical Research Centre

• Shinoda S

  Okayama Univ. Okayama Jpn

• Shinoda Sumio

  Fac. Of Sciences Okayama Univ. Of Sci.

• Shinoda Sumio

  Faculty Of Pharmaceutical Sciences Okayama University

• Narimatsu Shizuo

  Laboratories Of Health Chemistry Okayama University

• Narimatsu Shizuo

  Laboratories Health Chemistry Faculty Of Pharmaceutical Sciences Okayama University

• Narimatsu Shizuo

  Faculty Of Pharmaceutical Sciences Okayama University

• Miyoshi Shin-ichi

  Faculty Of Pharmaceutical Sciences Okayama University

• Ikai H

  Faculty Of Pharmaceutical Sciences Okayama University

• Ikai Hisato

  Faculty Of Pharmaceutical Sciences Okayama University

• Mutoh Nobuo

  Faculty Of Pharmaceutical Sciences Okayama University

• Shinoda S

  Faculty Of Pharmaceutical Sciences Okayama University

• Nakao H

  Department Of Infectious Diseases Research National Children's Medical Research Centre

• Miyoshi S

  Faculty Of Pharmaceutical Sciences Okayama University

• Yamamoto S

  Department Of Pharmacology And Pharmaceutics Graduate School Of Natural Science And Technology Kanaz

• Tsuzuki Daisuke

  Laboratories Of Health Chemistry Okayama University

• Nakao Hiroshi

  Department Of Infectious Diseases National Research Institute For Child Health And Development

• Yamamoto Shigeo

  Faculty Of Pharmaceutical Sciences Okayama University

• Nakao Hiroshi

  Department Of Cell Biology Kowa Research Institute

関連論文

• Occurrence and Characteristics of Class 1 and 2 Integrons in Clinical Bacterial Isolates from Patients in South China
• Effect of Psychotropic Drugs on the 21-Hydroxylation of Neurosteroids, Progesterone and Allopregnanolone, Catalyzed by Rat CYP2D4 and Human CYP2D6 in the Brain(Biochemistry)
• Analysis of Genetic Determinants Involved in Multiresistance in Clinical Strains Isolated from Renal Transplantation Recipients in Guangzhou, China
• Different Effects of Desipramine on Bufuralol 1"-Hydroxylation by Rat and Human CYP2D Enzymes(Pharmacology)
• Changes in the Enzymatic Properties of CYP2D6 by the Substitution of Phenylalanine at Position 120 by Alanine
• Alteration in Catalytic Properties of Human CYP2D6 Caused by Substitution of Glycine-42 with Arginine, Lysine and Glutamic Acid
• Identificaiton and Characterization of the sodA Genes Encoding Manganese Superoxide Dismutases in Vibrio parahaemolyticus, Vibrio mimicus, and Vibrio vulnificus
• Characterization of Vibrio parahaemolyticus Manganese-Resistant Mutants in Reference to the Function of the Ferric Uptake Regulatory Protein
• Cloning and Characterization of the ddc Homolog Encoding L-2,4-Diaminobutyrate Decarboxylase in Enterbacter aerogenes
• Siderophore Production of Vibrio parahaemolyticus Strains from Different Sources
• Cloning and Sequencing of the Vibrio parahaemolyticus fur Gene
• Occurrence of a Novel L-2,4-Diaminobutyrate Decarboxylase Activity in Some Species of Enterobacteriaceae, and Purification and Characterization of the Enzymes of Enterobacter aerogenes and Serratia marcescens
• Involvement of Vulnibactin and Exocellular Protease in Utilization of Transferrin-and Lactoferrin-Bound Iron by Vibrio vulnificus
• Demonstration of a Ferric Vibrioferrin-Binding Protein in the Outer Membrane of Vibrio parahaemolyticus
• Ecological Study of Vibrio cholerae in Aquatic Environments, Okayama
• Occurrence and Antigenic Heterogeneity of L-2,4-Diaminobutyrate Decarboxylase in Acinetobacter Species
• A Plasmidic Class 1 Integron from Five Pseudomonas aeruginosa Clinical Strains Harbored aacA4 and Nonsense-mutated cmlA1 Gene Cassettes
• Identification and Characterization of Class 1 Integron Resistance Gene Cassettes among Salmonella Strains Isolated from Healthy Humans in China
• Stereoselectivity in Bunitrolol 4-Hydroxylation in Liver Microsomes from Marmosets and Japanese Monkeys
• Mechanism of Hepatic Microsomal Oxidation of 11-Hydroxy-Δ^8-tetra-hydrocannabinol to 11-Oxo-Δ^8-tetrahydrocannabinol. Evidence for Hydration of the Aldehyde Formed
• INTERACTION OF CANNABINOIDS WITH HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM IN THE RAT
• Physicochemical and Biological Properties of an Extracellular Serine Protease of Aeromonas sobria
• 90°Phase-Matching Properties of YCa_4O(BO_3)_3 and Gd_x Y_Ca_4O(BO_3)_3
• Investigation of the Gd Variation of Gd_xY_Ca_4O(BO_3)_3 Crystal and Its Application : Structure and Mechanical and Thermal Properties of Condensed Matter
• Involvement of the Vibrio parahaemolyticus pvsC Gene in Export of the Siderophore Vibrioferrin
• Isolation and Characterization of a 1,3-Dichloro-2-Propanol-Degrading Bacterium
• An Inhibitor of VCAM-1 Expression and Its Implication as a Novel Treatment of Inflammatory Diseases
• Monoclonal Antibody to Shiga Toxin 1, Which Blocks Receptor Binding and Neutralizes Cytotoxicity
• Abundance of Vibrio parahaemolyticus Having tdh and/or trh Genes in an Area of Seto-Inland Sea, Japan
• Properties of Adenosine Triphosphate-Hydrolyzing Enzymes in Membrane Vesicles of Vibrio parahaemolyticus(Biological)
• Dichloromethane-Degrading Properties of Bacteria Isolated from Environmental Water
• カニクイザルにおける薬物代謝酵素およびトランスポーターmRNAの組織発現プロファイル
• Comparison of Inducibility of Multidrug Resistance (MDR)1, Multidrug Resistance-Associated Protein (MRP)1, and MRP2 mRNAs by Prototypical Microsomal Enzyme Inducers in Primary Cultures of Human and Cynomolgus Monkey Hepatocytes(Pharmacology)
• Comparison of Inducibility of Sulfotransferase and UDP-Glucuronosyltransferase mRNAs by Prototypical Microsomal Enzyme Inducers in Primary Cultures of Human and Cynomolgus Monkey Hepatocytes
• One-Point サンプリングデータのブートストラップ法による薬物速度論パラメータのヒストグラム解析
• Effects of Pretreatment of Hep G2 Cells with β-Naphthoflavone on Cytotoxicity of Propranolol and its Active Metabolite 4-Hydroxypropranolol
• Postmenopause-Like Bone Loss by Mammary Carcinoma Walker256/S Which Secretes Luteinizing Hormone-Releasing Hormone
• Role of Phosphodiesterase 4 Isoenzyme in Alkaline Phosphatase Activation by Calcitonin in Porcine Kidney LLC-PK_1 Cells
• Dual Regulation of Alkaline Phosphatase Activity by Calcitonin in Porcine Kidney Cells
• Amino-Acid Residues Involved in the Expression of the Activity of Escherichia coli TolC
• Proteolytic Activation of Vibrio mimicus (Vm) Major Outer Membrane Protein Haemagglutinin (HA) with Vm-HA/Protease : Implication for Understanding Bacterial Adherence
• Distribution of Virulence-Associated Genes in Vibrio mimicus Isolates from Clinical and Environmental Origins
• Purification of a Serine Protease of Vibrio parahaemolyticus and Its Characterization
• Detection of Viable Vibrio mimicus by Reverse Transcription-Polymerase Chain Reaction
• Detection of Virulence Associated Genes in Clinical Strains of Vibrio mimicus
• Analysis of Seawaters for the Recovery of Culturable Vibrio parahaemolyticus and Some Other Vibrios
• Isolation and Characterization of Cytochrome P450-Producing Bacteria from Various Environments
• Isolation of Dichloromethane-Degrading Bacteria from Drainage Water
• Analysis of Vibrio mimicus Clinical Strains by Arbitrarily Primed Polymerase Chain Reaction
• Presence of Hemolysin Genes (vmh, tdh and hlx) in Isolates of Vibrio mimicus Determined by Polymerase Chain Reaction
• The Hemagglutinating Action of Vibrio vulnificus Metalloprotease
• Detection of Genes Encoding Bholera Toxin (CT), Zonula Occludens Toxin (ZOT), Accessory Cholera Enterotoxin (ACE) and Heat-Stable Enterotoxin (ST) in Vibrio mimcus Clinical Strains
• Analysis of the Structural Gene Encoding a Hemolysin in Vibrio mimicus
• Molecular Epidemiological Studies of Vibrio cholerae in Bengal Region
• Phenotypic and Molecular Characteristics of Escherichia coli Isolated from Aquatic Environment of Bangladesh
• Induction of Cytochrome P450 1A1 in Mice by Repeated Oral Administration of Propranolol
• Inactivation of Rat Cytochrome P450 2D Enzyme by a Further Metabolite of 4-Hydroxypropranolol, the Major and Active Metabolite of Propranolol
• Biphasic Kinetics of Imipramine N-Oxidation in Rat Brain Microsomes
• Glutathione Transport Systems of the Budding Yeast Saccharomyces cerevisiae
• The Cytotoxin-Hemolysin Genes of Human and Eel Pathogenic Vibrio vulnificus Strains : Comparison of Nucleotide Sequences and Application to the Genetic Grouping
• A Hemolysin of Vibrio mimicus (VMH) Stimulates Cells to Produce ATP and Cyclic AMP Which Appear to Be Secretory Mediators
• Isolation and Characterization of a New Dichloromethane Degrading Bacterium, Ralstonia metallidurans, PD11
• Biological Nitrogen Removal from Waste-water by Using Immobilized Bacteria : Effective Nitrification by Immobilized Nitrifying Bacteria (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
• Characterization of a Shiga Toxin 1-Neutralizing Recombinant Fab Fragment Isolated by Phage Display System
• Evaluation of the Biofilm-Forming Ability and Genetic Typing for Clinical Isolates of Pseudomonas aeruginosa by Enterobacterial Repetitive Intergenic Consensus-Based PCR
• Contribution of Flavin-Containing Monooxygenase and Cytochrome P450 to Imipramine N-Oxidation in Rat Hepatic Microsomes
• Pulsed-field Gel Electrophoresis Typing of Multidrug-resistant Vibrio parahaemolyticus Isolated from Various Sources of Seafood
• Assimilation of Metal Ions Bound to Porphyrins or Porphyrin-Peptides by Vibrio vulnificus, a Human Pathogen Inhabiting Estuarine and Marine Environments
• Production of Antigenically Related Exocellular Elastolytic Proteases Mediating Hemagglutination by Vibrios
• Identification of 3-Phenyllactic Acid As a Possible Antibacterial Substance Produced by Enterococcus faecalis TH10
• Synthesis and Siderophore Activity of Vibrioferrin and One of Its Diastereomeric Isomers
• ヒトの肝細胞培養系を用いた新薬候補化合物曝露のCYP1A2およびCYP3A4誘導能の評価
• THE LECITHIN-DEPENDENT HEMOLYSIN PRODUCED BY VIBRIO PARAHAEMOLYTICUS : CHARACTERIZATION AS A NEW TYPE PHOSPHOLIPASE
• Oxidative Metabolism of Flunarizine and Cinnarizine by Microsomes from B-Lymphoblastoid Cell Lines Expressing Human Cytochrome P450 Enzymes
• Serological Determination of Vibrio parahaemolyticus and Its Application to Environmental Bacteriology (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology)
• Determination of amphetamine and methamphetamine in human hair by headspace solid-phase microextraction and gas chromatography with nitrogen-phosphorus detection
• Presence of LuxS/Al-2 Based Quorum-Sensing System in Vibrio mimicus : LuxO Controls Protease Activity
• FAST OSCILLATIONS OF THE ELECTRO-OCULOGRAM IN A SERIES OF NORMAL SUBJECTS
• Recording of Fast Oscillations of the Corneoretinal Potential with an Automated Electro-oculograph Nidek EOG-2 in a Series of Normal Subjects
• Identification and Characterization of Two Contiguous Operons Required for Aerobactin Transport and Biosynthesis in Vibrio mimicus
• Bioactivation of Morphine in Human Liver : Isolation and Identification of Morphinone, a Toxic Metabolite(Miscellaneous)
• Secretion of Albumin and Induction of CYP1A2 and CYP3A4 in Novel Three-dimensional Culture System for Human Hepatocytes using Micro-space Plate
• ROLE OF THE PROTEASE IN VIBRIO VULNIFICUS INFECTION
• Actions of Vibrio vulnificus Metalloprotease on Human Plasma Proteinase-Proteinase Inhibitor Systems : A Comparative Study of Native Protease with Its Derivative Modified by Polyethylene Glycol
• Marinesco-Sjogren syndrome with reduced cytochrome c oxidase in muscle.
• Thyroid function in premature infants.
• Reproducibility of a noisy limit-cycle oscillator induced by a fluctuating input
• Two Genes Involved in the 1,3-Diaminopropane Production Pathway in Haemophilus influenzae
• Activity of rheumatoid arthritis and urinary pyridinoline and deoxypyridinoline
• Proteases Produced by Vibrios
• Siderophore-Mediated Utilization of Transferrin- and Lactoferrin-Bound Iron by Acinetobacter baumannii
• A Case of Rhegmatogenous Retinal Detachment in Congenital Glaucoma
• Determination of daidzein and genistein in soybean foods by automated on-line in-tube solid-phase microextraction coupled to high-performance liquid chromatography
• Uniform-Sized Molecularly Imprinted Polymer Material for Propranolol. Recognition of Propranolol and Its Metabolites
• Immunochemical Identification of Marine Pathogenic Vibrios
• Conversion of viable but nonculturable Vibrio cholerae to the culturable state by co-culture with eukaryotic cells
• Conversion of viable but nonculturable enteric bacteria to culturable by co-culture with eukaryotic cells
• Abundance of Vibrio parahaemolyticus Having tdh and/or trh Genes in an Area of Seto-Inland Sea, Japan
• Ecological Study of Pathogenic Vibrios in Aquatic Environments
• Detection of Viable Vibrio mimicus by Reverse Transcription-Polymerase Chain Reaction.

もっと見る 閉じる

スポンサーリンク