キトサンオリゴ糖の静脈内投与がマウス口腔粘膜の創傷治癒に及ぼす影響

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Chitosan is a natural macromolecule obtained by deacetylating chitin in a concentrated alkaline solution. Chitosan is pharmacologically active, having been shown to accelerate wound healing, inhibit tumor growth, and lower serum cholesterol. A low molecular weight from of chitosan, chitosan oligosaccharide, has also been developed, and its pharmacological activities are currently being investigated. However, the pharmacological actions that occur when chitosan oligosaccharide is administered systemically have not been fully elucidated. We previously investigated the effects of oral administration of chitosan oligosaccharide on wound healing of the oral mucosa in vitro and in vivo, and here, we investigated the effects of intravenous administration of chitosan oligosaccharides on healing of oral mucosal injury in mice. An Nd-YAG laser was used to damage the oral mucosa, and then various concentrations of chitosan oligosaccharide were intermittently administered intravenously. As a control, one group of mice under-went the wounding process, but received no chitosan. After a certain period, the damaged oral mucosa was excised, and tissue sections were prepared for morphological observation. When compared to controls, animals treated with chitosan oligosaccharide demonstrated faster resolution of tissue unevenness and new capillary vessel formation, and greater fibroblast induction and subsequent collagen fiber production. Hence, intravenous administration of chitosan oligosaccharide might accelerate wound healing after oral mucosal injury.
奥羽大学の論文

キトサンオリゴ糖の静脈内投与がマウス口腔粘膜の創傷治癒に及ぼす影響

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