カテキンによる根管内細菌の抑制効果

概要

論文の詳細を見る
Catechin in green and black tea has a rangeof pharmacological effects, including antimicrobial activity. The antimicrobial action of catechin is enhanced by concurrent use of β-lactams, and various studies have been conducted to determine the synergistic effects of catechin and antibiotics. Here, the authors investigated the antimicrobial effects of catechin monotherapy and catechin and β-lactam combination therapy in microbes collected from the root canals of teeth in the early stages of therapy for chronic apical periodontitis and microbes collected from teeth with intractable apical periodontitis, as well as Porphyromonas gingivalis and Prevotella intermedia. In this study, inhibition rings were measured using the pulp disc method, and the colonies formed under each set of conditions were observed. The results of the study were as follows; 1. Growth of P. gingivalis and P. intermedia was inhibited by one-third of the amount of catechin required for complete growth inhibition of microbial flora inside human root canals. 2. Catechin monotherapy was effective in suppressing microbes inside the root canals of teeth in the early stages of therapy for chronic apical periodontitis. Combining cefmetazon further enhanced this suppressive effect. 3. The suppressive effect of catechin was not substantial against Gram-positive cocci believed to be resistant to β-lactams and collected from the root canals of teeth with intractable apical periodontitis. However, the suppressive effects of catechin were marked against Candida albicans collected from the same area.
特定非営利活動法人日本歯科保存学会の論文
2006-12-31

カテキンによる根管内細菌の抑制効果

スポンサーリンク

概要

著者

関連論文

スポンサーリンク