Cerebral Endothelial Injury in Elderly Patients With Severe Head Injury Measured by Serum Thrombomodulin and von Willebrand Factor
スポンサーリンク
概要
- 論文の詳細を見る
Elevated serum levels of thrombomodulin (TM) and von Willebrand factor (vWf) are good indicators of injury and activation of cerebral endothelium in patients with severe simple head injury. The present study evaluated cerebral endothelial injury or activation as the serum levels of TM and vWf in elderly and younger patients with similar brain trauma, to evaluate the primary parenchymal injury of the brain. Patients with head injury were classified into the young group (16-30 years), the middle-aged group (31-65 years), and the elderly group (over 66 years). There was no difference in Glasgow Coma Scale on admission between the three groups. The serum levels of TM and vWf at 2 hours after injury were significantly higher in the elderly group than in the other groups. However, the serum levels of TM and vWf were not significantly different at 3 and 7 days after injury. Cerebral endothelial activation and injury were significantly higher in elderly patients just after head injury than in younger patients, which suggests that greater sensitivity to endothelial injury and activation may be important in the worse outcome after head injury in elderly patients compared with younger patients.
- 社団法人 日本脳神経外科学会の論文
- 2007-09-15
著者
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Kawai Makoto
Department of Cardiology, Jikei University
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YAMAMOTO Yasuhiro
Department of Chemistry, Faculty of Science, Toho University
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KUSHIMOTO Shigeki
Department of Emergency and Critical Care Medicine, Nippon Medical School Hospital
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SATO Hidetaka
Department of Applied Physics, Graduate School of Engineering, Tohoku University
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Sato Hidetaka
Department Of Emergency And Critical Care Medicine Main Hospital Nippon Medical School
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Sato Hidetaka
Department Of Applied Physics Faculty Of Engineering Tohoku University
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Fuse Akira
Department Of Emergency And Critical Care Medicine Nippon Medical School
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ARAKI Takashi
Department of Botany, Graduate School of Science, Kyoto University
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Yokota Hiroyuki
Department Of Emergency And Critical Care Nippon Medical School
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Yokota Hiroyuki
Department Of Emergency And Critical Care Medicine Nippon Medical School
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Kushimoto Shigeki
Department Of Emergency And Critical Care Medicine Nippon Medical School
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Araki Takashi
Department Of Botany Division Of Biological Science Graduate School Of Science Kyoto University
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Yamamoto Yasuhiro
Department Of Emergency And Critical Care Nippon Medical School
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Kawai Makoto
Department Of Emergency And Critical Care Medicine Main Hospital Nippon Medical School
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ATSUMI Takahiro
Department of Emergency and Critical Care Medicine, Main Hospital, Nippon Medical School
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KOIDO Yuichi
Department of Emergency and Critical Care Medicine, Main Hospital, Nippon Medical School
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Koido Yuichi
Department Of Emergency And Critical Care Medicine Main Hospital Nippon Medical School
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Koido Yuichi
Department Of Emergency And Critical Care Medicine Nippon Medical School
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Atsumi Takahiro
Department Of Emergency And Critical Care Medicine Main Hospital Nippon Medical School
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Yokota Hiroyuki
Department Of Emergency And Critical Care Medicine Main Hospital Nippon Medical School
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Araki Takashi
Department Of Emergency And Critical Care Medicine Main Hospital Nippon Medical School
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Kawai Makoto
Department Of Cardiology Jikei University School Of Medicine
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Yamamoto Yasuhiro
Department Of Emergency And Critical Care Medicine Main Hospital Nippon Medical School
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Yamamoto Yasuhiro
Department Of Critical Care Medicine Main Hospital Nippon Medical School
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Fuse Akira
Department Of Emergency And Critical Care Medicine Graduate School Of Medicine Nippon Medical School
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Yokota Hiroyuki
Department Of Emergency And Critical Care Medicine Graduate School Of Medicine Nippon Medical School
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YOKOTA Hiroyuki
Department of Emergency and Critical Care Medical Center, Nippon Medical School
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FUSE Akira
Department of Emergency and Critical Care Medical Center, Nippon Medical School
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