Multiple Myeloma with a Variant Burkitt-type Translocation, t(2;8)(p12;q24), Associated with Hyperammonemia
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概要
- 論文の詳細を見る
We report an 82-year-old Japanese woman with multiple myeloma (MM). She developed disorientation due to hyperammonemia after melphalan and prednisolone therapy and abruptly died with a rapid clinical course. Karyotypic analysis of bone marrow showed complex abnormalities including a variant Burkitt-type translocation, t(2;8)(p12;q24), but the patient had IgG-λ type M-proteinemia. Although patients with MM associated with hyperammonemia have been sporadically reported and their prognosis is poor, specific chromosomal abnormalities in the lesion have not been well characterized. It is, therefore, important to accumulate such patients to find a possible relationship between hyperammonemia and chromosomal abnormalities.
著者
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YAMAMOTO Yasuhiro
Department of Chemistry, Faculty of Science, Toho University
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Nakamine Hirokazu
Division Of Pathology And Immunology Kansai University For Health Science
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Konoike Yoshizumi
Department Of Internal Medicine Heisei Memorial Hospital
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NAKAMURA Shinobu
Department of Biological Science, Faculty of Science, Kumamoto University
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Morii Takeshi
The Second Department of Internal Medicine, Nara Medical University
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Kimura Hiroshi
The Second Department of Internal Medicine, Nara Medical University
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