BIOLOGICAL MONITORING OF METABOLITES OF SARIN AND ITS BY-PRODUCTS IN HUMAN URINE SAMPLES

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概要

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• More than 20,000 passengers of Tokyo underground trains were intoxicated with warfare toxic chemicals. Most of the patients examined had marked miosis and decreased serum cholinesterase activity. Transient increase of serum CDK activity after 3 days of the exposure was the another sign. We intensively analyzed the metabolites in the urine of 4 patients. The following analytic results indicated the exposure to sarin as well as contaminated compounds such as diisopropyl methylphosphonate (DIMP), ethyl methylphosphonate fluoridate (EMPF, or ethylsarin), diethyl methylphosphonate (DEMP), and ethyl isopropyl methylphosphonate (EIMP). (1) Isopropanol (IPA) and ethanol (EtOH) were detected of large quantities in the urine samples, and were thought to be derived from sarin and the sarin counterpart, EMPF, DIMP, DEMP and EIMP. (2) Monoalkyl methylphosphonic acids (isopropyl methylphosphonic acid (IMPA) and ethyl methylphosphonic acid (EMPA) also were excreted in large amounts with taking the simlllllllllllllar excretion pattern of IPA and EtOH. (3) The metabolite only derived from sarin and ethylsarin is F anions whose integral output in the urine was less than the equimolar level of the excreted (IMPA+EMPA+IPA+EtOH). (4) Other corroborative findings were low lethality : of more than 5,510 patients treated, 11 were acutely dead. (5) Nine exposed males had higher sister chromatid exchange (SCE) rate (5.00±1.48/cell) than the control (3.81±0.697/cell), because dialkyl methylphosphonates seemed to have alkylating activity and producing DNA adducts. The SCE rate also increased after the in vitro exposure of lymphocytes to dialkyl methylphosphonates.

• 1998-07-24

著者

• YAMAMOTO Yasuhiro

  Department of Chemistry, Faculty of Science, Toho University

• Mashiko Kunihiro

  Department of Critical Care Medicine, Chiba Hokusoh Hospital, Nippon Medical School

• LI Qing

  Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Me

• KATSUMATA Masao

  Department of Applied Physics, Faculty of Engineering, Tohoku University

• MINAMI Masayasu

  Department of Hygiene and Public Health, Nippon Medical School

• Mashiko Kunihiro

  Department Of Emergency And Critical Care Medicine Nippon Medicalschool

• Wang Zhiyu

  Department Of Hygiene And Public Health Nippon Medical School

• Minami M

  Nippon Medical School

• Minami Masayasu

  Department Of Hygiene And Public Health Nippon Medical School

• Katsumata Masao

  Dept. Hyg. Publ. Hlth. Nippon Medical School

• Hui Da-Mei

  Department of Hygiene and Public Health, Nippon Medical School

• Inagaki Hirofumi

  Department of Hygiene and Public Health, Nippon Medical School

• Inuzuka Shou

  Department of Emergency and Critical Care Medicine, Nippon Medical School

• Ootsuka Toshifumi

  Department of Emergency and Critical Care Medicine, Nippon Medical School

• A.Boulet Caimille

  Defense Research Establishment Suffield, Medicine Hat

• G.Clement John

  Defense Research Establishment Suffield, Medicine Hat

• Inuzuka Shou

  Department Of Emergency And Critical Care Medicine Nippon Medical School

• Inagaki H

  Nippon Medical School Tokyo Jpn

• Inagaki Hirofumi

  Department Of Hygiene And Public Health Nippon Medical School

• G.clement John

  Defense Research Establishment Suffield Medicine Hat

• A.boulet Caimille

  Defense Research Establishment Suffield Medicine Hat

• Katsumata Masao

  Department Of Applied Physics Faculty Of Engineering Tohoku University

• Hui Da-mei

  Department Of Hygiene And Public Health Nippon Medical School

• Ootsuka Toshifumi

  Department Of Emergency And Critical Care Medicine Nippon Medical School

• Li Qing

  Department Of Biology Huaibei Coal Normal College

• Minami Masayasu

  Chronic Fatigue Research Center Institute For Science Of Labour

• Li Qing

  Department Of Hygiene And Public Health Nippon Medical School

• Yamamoto Yasuhiro

  Department Of Emergency And Critical Care Medicine Nippon Medical School

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