Lower Extracellular Glucose Level Prolonged in Elderly Patients With Severe Traumatic Brain Injury : A Microdialysis Study
スポンサーリンク
概要
- 論文の詳細を見る
Age may be an independent predictor of outcomes in traumatic brain injury (TBI), but the causes of the poor outcomes in elderly patients remain unclear. To clarify the differences between elderly and young patients with TBI, brain metabolism parameters were monitored with the microdialysis method in 30 patients with severe TBI (Glasgow Coma Scale scores 3-8). The microdialysis probe was inserted in the penumbra area of the brain and extracellular levels of glucose, glutamate, glycerol, lactate, and pyruvate were measured hourly for the initial 168 hours (7 days) after operation. The lactate/pyruvate ratio, which is considered to be a good indicator of neuronal ischemia, was also calculated. The patients were divided into the elderly group aged 65 years or older and the young group aged less than 65 years, and the biochemical markers were compared daily between these two groups. The value of extracellular glucose concentration was significantly lower in the elderly group than in the young group, and continued until the 7th day after injury. Moreover, the lactate/pyruvate ratio peaked on the 5th day after injury in the elderly group, later than in the young group. We concluded that neural vulnerability persisted longer in elderly patients than in young patients with TBI, and this should be considered to prevent the occurrence of additional secondary brain injury.
- 2011-04-15
著者
-
WATANABE AKIHIRO
Department of Pediatrics, Niigata Cancer Center Hospital
-
Fuse Akira
Department Of Emergency And Critical Care Medicine Nippon Medical School
-
Yokota Hiroyuki
Department Of Emergency And Critical Care Nippon Medical School
-
Yokota Hiroyuki
Department Of Emergency And Critical Care Medicine Nippon Medical School
-
Kushimoto Shigeki
Department Of Emergency And Critical Care Medicine Nippon Medical School
-
Yokota Hiroyuki
Department Of Emergency And Critical Care Medicine Main Hospital Nippon Medical School
-
Matsumoto Gaku
Department Of Emergency And Critical Care Medicine Nippon Medical School
-
YOKOBORI Shoji
Department of Emergency and Critical Care Medicine, Nippon Medical School
-
ONDA Hidetaka
Department of Emergency and Critical Care Medicine, Nippon Medical School
-
MASUNO Tomohiko
Department of Emergency and Critical Care Medicine, Nippon Medical School
-
Onda Hidetaka
Department Of Emergency And Critical Care Medicine Nippon Medical School
-
Yokobori Shoji
Department Of Emergency And Critical Care Medicine Nippon Medical School
-
Masuno Tomohiko
Department Of Emergency And Critical Care Medicine Nippon Medical School
-
Watanabe Akihiro
Department Of Emergency And Critical Care Medicine Nippon Medical School
-
Watanabe Akihiro
Department Of Applied Chemistry Okayama University Of Science
-
Fuse Akira
Department Of Emergency And Critical Care Medicine Graduate School Of Medicine Nippon Medical School
-
Yokota Hiroyuki
Department Of Emergency And Critical Care Medicine Graduate School Of Medicine Nippon Medical School
-
YOKOTA Hiroyuki
Department of Emergency and Critical Care Medical Center, Nippon Medical School
-
FUSE Akira
Department of Emergency and Critical Care Medical Center, Nippon Medical School
関連論文
- Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis : a multicenter prospective study
- Glomerular dysfunction, independent of tubular dysfunction, induced by antineoplastic chemotherapy in children
- Hemophagocytic lymphohistiocytosis with preceding neurologic signs and neutrophilia
- Cerebral Vasospasms After Intraventricular Hemorrhage From an Arteriovenous Malformation : Case Report
- Multicenter prospective study of procalcitonin as an indicator of sepsis
- Study on the Effect of Ultrasound Condition upon Suppression of Cancer Cells Proliferation : Consideration of Ultrasound Exposure System with Balloon
- Pancreatographic findings in idiopathic acute pancreatitis
- Intraoperative Radiation Therapy for Pancreatic Adenocarcinoma : The Komagome Hospital Experience
- Expression of multidrug resistance-related genes does not contribute to risk factors in newly diagnosed childhood acute lymphoblastic leukemia
- Bilateral Traumatic Abducens Nerve Palsy Associated With Skull Base Fracture : Case Report
- Increased Regional Interleukin-4 During the Acute Stage of Severe Intracranial Disorders
- Granulocyte-colony stimulating factor-producing esophageal carcinoma: serum level as a marker for monitoring the effects of treatment
- Metastatic Colon Carcinoma Found Within an Inguinal Hernia Sac : Report of a Case
- Cerebral Endothelial Injury in Elderly Patients With Severe Head Injury Measured by Serum Thrombomodulin and von Willebrand Factor
- 5. Survey for the Medical Needs and Living Condition in the 2004 Sri Lanka Tsunami Disaster
- Effect of probiotic bacterial strains of Lactobacillus, Bifidobacterium, and Enterococcus on enteroaggregative Escherichia coli
- Alveolar Echinococcosis of the Liver in a Tokyo Resident with an Unknown Route of Infection : Report of a Case
- Transverse Colonic Cancer Presenting as an Anterior Abdominal Wall Abscess : Report of a Case
- Immediate Postoperative Angiographic Embolization After Damage Control Surgery for Liver Injury : Report of a Case
- Cloning of cDNA Coding for Guinea Pig Liver Transglutaminase(Biological Chemistry)
- Monoclonal Antibody to Noncatalytic Subunit of Bovine Plasma Factor XIII: Selective Isolation of Catalytic Subunit(Biological Chemistry)
- Regional cerebral blood flow in delirium patients
- Adenosquamous Carcinoma of the Remnant Stomach: Report of a Case
- Lower Extracellular Glucose Level Prolonged in Elderly Patients With Severe Traumatic Brain Injury : A Microdialysis Study
- Integrated Chemical Process. One-Pot Preparation of Olefins by Alkylation and Desulfonylation
- Modulation Mechanism of C-mpl Gene Expression in Human Megakaryoblastic CMK Cells
- Traumatic Renal Artery Occlusion Treated with an Endovascular Stent-The Limitations of Surgical Revascularization : Report of a Case
- Allogeneic Transplantation of CD34^+ Peripheral Blood Progenitor Cellsfor Severe Combined Immunodeficiency
- A New Method of Determining the Rate Constants for State-to-state Vibrational Relaxation : An Integrated Profiles Method
- An introduction of simulation-based influenza education drill for medical students in Japan : Effective "learn-by-doing" method for team-based medicine
- Relationship between Electrochemical Pre-Treatment and Cycle Performance of a Li-Rich Solid-Solution Layered Li1−α[Ni0.18Li0.20+αCo0.03Mn0.58]O2 Cathode for Li-Ion Secondary Batteries
- Clinical Analysis of Spinal Cord Injury With or Without Cervical Ossification of the Posterior Longitudinal Ligament, Spondylosis, and Canal Stenosis in Elderly Head Injury Patients
- Accuracy of Left Atrial Imaging Using NavX Velocity System: Initial Experience and Validation
- Study on the Effect of Ultrasound Condition upon Suppression of Cancer Cells Proliferation —Consideration of Ultrasound Exposure System with Balloon—
- Measurement of Inflammatory Cytokines and Thrombomodulin in Chronic Subdural Hematoma
- A Prospective Analysis of Disseminated Intravascular Coagulation in Patients with Infections
- Neuropsychological recovery in pediatric patients with acute subdural hematoma treated with mild hypothermia therapy : Report of two cases
- Clinical efficacy and safety of arbekacin sulfate in patients with MRSA sepsis or pneumonia : a multi-institutional study
- Traumatic Cerebrovascular Injury Following Severe Head Injury : Proper Diagnostic Timetable and Examination Methods