Calorimetric Analysis of the Effects of Penicillin G, Ampicillin and Polymyxin B on the Growth of Escherichia coli (Microbiology & Fermentation Industry)

概要

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Calorimetric analysis was performed of the effects of penicillin G, ampicillin and polymyxin B on escherichia coli grown on bouillon medium at pH 6.2 and 37℃. The presence of any one one of these drugs shifted the patterns of growth thermograms toward longer incubation periods, although the growth rate constant remained almost unchanged. The changes in the thermogram patterns were analyzed by means of a simple mathematical model and parameters needed to characterize the action ofo the drugs on the growth of E. coli were determined. The drug concentrations at which the number of viable cells at the start of incubation decreased by half during the incubation were 6.94, 0.46 and 0.04μmol dm^<-3> for penicillin G, ampicillin and polymyxin B, respectively. Drug potency curves were drawn for the three drugs using the parameters determined.
社団法人日本農芸化学会の論文
1988-09-23