Quantitative and Morphological Studies of Argyrophilic Nucleolar Organizer Regions (AgNORs) in Gallbladder Cancers

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概要

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• The AgNORs number, AgNORs-area and AgNORs-morphologic pattern of 43 cases of gallbladder cancer, 15 of gallbladder adenoma and 10 of normal gallbladder epithelium were investigated with the aid of an image analyzer. The AgNORs-number and AgNORs-area parameters demonstrated statistically significant differences. In particular, AgNORs-area changed in proportion to histologic malignant grading, while AgNORs-number varied significantly between low and high malignancies. Morphologic patterns of AgNORs-dots could be divided into five groups according to its number, size, shape and location. Using our classification criteria, gallbladder cancers could thereby be clearly discriminated from normal tissue with adenomas, occupying an intermediate position. In conclusion, assessment of AgNORs-number, AgNORs-area and morphology might provide a useful aid in clarifying the biological natures of malignant and benign gallbladder tumors.

• 北里大学の論文
• 1992-12-31

著者

• TAKANO Yasuo

  Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences

• OKUDAIRA Masahiko

  Department of Pathology, Odawara Municipal Hospital

• KAKITA AKIRA

  Department of Surgery, Kitasato University

• KIDA Yoshiki

  Department of Gastroenterology, Emergency and Critical Care Medicine, Kitasato University Hospital

• Kakita Akira

  Department Of Gastroenterology Kitasato University

• Kida Yoshiki

  Department Of Gastroenterology Kitasato University East Hospital

• Takano Yasuo

  Department Of Anatomy Kochi Medical School

• Yoshida Hideyo

  Department Of Epidemiology Tokyo Metropolitan Institute Of Gerontology

• Okudaira Masahiko

  Department Of Pathology Faculty Of Medicine Kitazato University

• Suzuki Tadamichi

  Department of Pathology, and Surgery, Kitasato University School of Medicine

• Kim Hunkyung

  Department Of Epidemiology Tokyo Metropolitan Institute Of Gerontology

• Ishizaki Tatsuro

  Department Of Health Economics And Quality Management Kyoto University

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