Intracellular Fate of Mycobacterium leprae in Cultured Macrophages
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概要
- 論文の詳細を見る
Mycobacterium leprae is an obligate intracellular parasite and grows within mononuclear phagocytes. In clinical cases, M. leprae reaches enormous numbers in the macrophage-rich granulomas of leprosy. Peritoneal macrophages from CBA mice were cultured in Waymouth medium containing fresh horse serum. These cells were infected with M. leprae Thai-53 obtained by nude mice inoculation. Significant multiplication of the acid-fast bacilli in the macrophages was observed 3 weeks after inoculation. On the other hand, there was no increase in the number of heat-killed M. leprae 3 weeks after ingestion. M. leprae also showed growth in macrophages from human healthy peripheral blood 3 weeks after infection.
- 北里大学の論文
- 1990-12-31
著者
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Osawa Nobutaka
Department Of Microbiology Kitasato University School Of Medicine
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Akiyama Takehisa
Department of Microbiology, Kitasato University School of Medicine
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Akiyama T
Kitasato Univ. School Of Medicine
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Akiyama Takehisa
Department Of Microbiology Kitasato University School Of Medicine
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AKIYAMA TAKEHISA
Department of Bacteriology, School of Medicine, Keio University
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