Killing Effects of Antimicrobial Agents on Intracellular Salmonella enteritidis or Mycobacterium tuberculosis in Cultured Murine Macrophages
スポンサーリンク
概要
- 論文の詳細を見る
Penicillin G (PCG) and streptomycin (SM) in cell culture medium inhibited extracellular growth of bacteria. Multiplication of Salmonella enteritidis, which belong to intracellular parasite, were observed one to three days after ingestion in the presence of 20μg/ml of SM and 40μg/ml of PCG in vitro. SM and PCG do not affect growth of intracellular bacteria. On the other hand, chloramphenicol (CP) and ofloxacin (OFLX) in the medium have a killing effect on the intracellular bacteria one or two days after ingestion. CP and OFLX pass through macrophage membrane. It may be difficult for PCG, SM and tetracycline (TC) to pass through the membrane but TC entrapped in liposome inhibited the growth of intracellular S. enteritidis. OFLX also has a killing effect on intracellular Mycobacterium tuberculosis. In comparison of the growth rate on day 9, number of bacteria on from cover slips from the experimental group thirty times less than that from the control.
- 北里大学の論文
- 1991-04-30
著者
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Osawa Nobutaka
Department Of Microbiology Kitasato University School Of Medicine
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Akiyama Takehisa
Department of Microbiology, Kitasato University School of Medicine
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