Host Response to Infection with a Salmonella enteritidis in a Susceptible and a Resistant Strain of Mice

概要

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The mechanisms of natural resistance in murine salmonellosis are complex. Various strains of mouse were tested for challenge infection of 10^<-7> mg (3×10^2) of fully virulent Salmonella enteritidis 116-54 intravenously. Mean survival days of DDNs-1, DDNs-6, C57BL/6, BALB/c, C3H, A/J and C57L were 4.1, 4.2, 5.0, 5.2, 7.7, 10.0 and 10.3 respectively. Survival rate of SWM, SJL, ATH and ATL was 20-63%, 10%, 20% and 42% respectively. Survival rate of F_1, such as (C3H×SWM) F_1, and (SWM×C57L) F_1 were 33-66% and 90-100%. Survival rate of F_1 mice was higher than that of compare to parent mice. In the course infection of attenuated strain of S. enteritidis SER of DDNs-6 and (SWM×C57L) F_1, the numbers of bacteria in the liver and spleen in DDNs-6 increased after the infection, reached the maximum about 9th days of infection and thereafter gradually decreased. On the other hand, numbers of bacteria in (SW×C57L) F_1 mice decreased 3 days after infection and after gradually increased. Splenomegaly was much more pronounced and persisted longer in DDNs-6 mice than in (SWM×C57L) F_1 mice. Three weeks after attenuated live vaccine immunization mice were inoculated with virulent strain of the salmonella, 100% of F_1 mice were survived but 5% of DDNs-6 were survived.
北里大学の論文
1991-04-30