Molecular Biology of Host-Parasite Relationship in Infectious Diseases, Part 1
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概要
- 論文の詳細を見る
In the present study, we performed the DNA-DNA hybridization test by the use of DNAs obtained separately from bacilli of various species of Salmonella and from mammalian cells of various species. Our purpose was to investigate the correlation between the manner by which an infected host responds to microbial invasion and the base sequence homology of DNAs from hosts and parasites. It was, consequently, found that the homology between host's DNA and the DNA from bacteria, which can behave as obligate or facultative intracellular parasites in the host, was significantly greater than the homology between the DNA of bacteria growing only extracellularly and its host DNA. From these data it may be suggested that there is a possibility that the previously reported antigenic alteration occurring in infected cells following intracellular growth of parasites is an expression of genetic recombination between the genome brought in by the parasites and that of host.
- 北里大学の論文
- 1979-04-30
著者
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Esashika Ikuko
Department Of Microbiology Kitasato University School Of Medicine Sagamihara Kanagawa-ken Japan.
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Esashika Ikuko
Department Of Microbiology Kitasato University School Of Medicine.
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Akiyama Takehisa
Department Of Microbiology Kitasato University School Of Medicine
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Tozawa Hideki
Department of Immunology, Kitasto University School of Hygienic Sciences.
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Tozawa Hideki
Department Of Immunology Kitasto University School Of Hygienic Sciences.
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AKIYAMA TAKEHISA
Department of Bacteriology, School of Medicine, Keio University
関連論文
- Effects of Protomin, Rifampicin or Clofazimine Entrapped in Liposomes on Mycobacterium leprae in Cultured Murine Macrophages
- Intracellular Fate of Mycobacterium leprae in Cultured Macrophages
- Antigenic Alteration on Animal Cell Infected with Intracellular Parasites and Its Possible Effect on Natural Resistance of the Animals
- Antimicrobial Agents Entry into Murine Cultured Macrophages
- Effects of Antimicrobial Agents Entrapped in Liposomes on Salmonella enteritidis and Mycobacterium lepraemurium in Cultured Murine Macrophages
- Experimental Leptospirosis with Special Reference to Cell-Mediated Immunity
- Antigenic Alteration on the Membrane of Cells from Animals Infected with Intracellular Parasites
- Molecular Biology of Host-Parasite Relationship in Infectious Diseases, Part 1
- STUDIES ON THE IMMUNITY OF EXPERIMENTAL TYPHOID:III. A COMPARATIVE STUDY OF ACTIVE AND PASSIVE IMMUNIZATIONS AGAINST THE INFECTION OF MICE WITH SALMONELLA ENTERITIDIS
- MACROPHAGE MIGRATION INHIBITION TEST: EXPERIMENTAL AND CLINICAL STUDIES
- STUDIES ON EXPERIMENTAL TYPHOID: BACTERIAL MULTIPLICATION AND HOST CELL RESPONSE AFTER INFECTION WITH SALMONELLA ENTERITIDIS IN MICE IMMUNIZED WITH LIVE AND KILLED VACCINES